Pyrantel
Based on 1 publication(s) in Google Scholar
Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.
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- CAS. Nr.: 15686-83-6
- Formel: C11H14N2S
- Molecular Weight:206.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pyrantel
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Biologische Aktivität
Pyrantel (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A. suum
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Concentration:10 nM-10 µM
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Incubation Time:72 h
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Result:Inhibited A. suum with a pEC50 value of 7.24.
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Cell Line:N. americanus
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Concentration:0-168.2 M (0-100 µg/mL)
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Incubation Time:72 h
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Result:Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected)[2].
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Dosage:10 mg/kg
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Administration:Oral administration; single.
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Result:Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
Chemical Information
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CAS. Nr. 15686-83-6
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Molecular Weight 206.31
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Formel C11H14N2S
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SMILES
CN1CCCN=C1/C=C/C2=CC=CS2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319
Reinheit & Dokumentation
Verweise
[1]. Martin RJ, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [Content Brief]
[2]. Tritten L, et al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5(12):e1457. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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