Roridin A
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Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita).
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- Reinheit: 99.49%
- CAS. Nr.: 14729-29-4
- Formel: C29H40O9
- Molecular Weight:532.62
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Fungal Metabolite |
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Cell Line
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Type | Value | Description | References |
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| K562 | IC50 |
0.0071 μM
Compound: 13
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Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay
Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay
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[PMID: 31117520] |
| SW 1116 | IC50 |
0.21 μM
Compound: 13
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Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay
Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay
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[PMID: 31117520] |
Roridin A (24-500 μg/mL) completely inhibits cucumber root knot formation induced by Meloidogyne incognita at the dose of 24 μg/mL, and reduces root knot formation at the dose of 500 μg/mL[2].
Roridin A (7 days) potently induces the death of juveniles of Meloidogyne incognita (southern root-knot nematode) hatched from treated eggs, with an LD50 of 1.50 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Arabidopsis thaliana[1]
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Dosage:0.6 μM, 2 μM, 6 μM, 20 μM, 60 μM
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Administration:incorporated into solid growth medium at seeding; continuous exposure
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Result:Showed no inhibitory effect on plant growth, no delay in bolting or flowering time, and no impact on stem length relative to control at 0.6 μM.
Did not delay bolting time, but delayed flowering time; inhibited pollen development, resulting in anthers with collapsed structures and no viable pollen, and blocked female fertility (no seed formation via hand pollination with untreated pollen); reduced stem length to first flowering to 17 mm at 2 μM.
Completely inhibited plant growth (no germination) at 6 μM, 20 μM, and 60 μM.
Chemical Information
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CAS. Nr. 14729-29-4
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Appearance Solid
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Molecular Weight 532.62
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Formel C29H40O9
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Color White to off-white
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SMILES
C[C@@H]1CCO[C@@H]([C@H](O)C)/C=C\C=C/C(O[C@@H]2C[C@@H]3[C@@]4(CO4)[C@@]2(C)[C@@]5(COC([C@H]1O)=O)CCC(C)=C[C@H]5O3)=O
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Structure Classification
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Initial Source
Cylindrocarpon sp
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 10 mg/mL (18.78 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8775 mL | 9.3876 mL | 18.7751 mL | 46.9378 mL |
| 5 mM | 0.3755 mL | 1.8775 mL | 3.7550 mL | 9.3876 mL | |
| 10 mM | 0.1878 mL | 0.9388 mL | 1.8775 mL | 4.6938 mL | |
| 15 mM | 0.1252 mL | 0.6258 mL | 1.2517 mL | 3.1292 mL |
Roridin A Related Classifications
HY-N9599 Related Classifications
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