Anticancer agent 318
Anticancer agent 318 (Compound 8 (6)) is a selective anticancer agent. Anticancer agent 318 can be metabolized by CYP1A1, CYP1A2 and CYP1B1. After bioactivation, Anticancer agent 318 exerts antiproliferative activity in breast cancer cells expressing CYP1. Anticancer agent 318 can be used in the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2482789-24-0
- Formula: C20H17NO4
- Molecular Weight:335.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP1A1 |
CYP1A2 |
CYP1B1 |
The anticancer agent 318 potently inhibits the proliferation of CYP1-expressing breast cancer cell lines MDA-MB-468 (IC50 = 0.08 μM) and TCDD-induced MCF-7 (IC50 = 0.006 μM), shows no toxicity toward non-tumorigenic MCF-10A cells (IC50 = 100 μM), and its activity depends on CYP1-mediated bioactivation[1].
The anticancer agent 318 (0-30 min) is metabolized by CYP1A1, CYP1A2 and CYP1B1 (but not CYP3A4) enzymes, producing four distinct metabolites via demethylenation, O-demethylation and hydroxylation reactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2482789-24-0
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Molecular Weight 335.35
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Formula C20H17NO4
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SMILES
COC1=CC(OC)=C(C=C1)C2=CC(C3=CC4=C(OCO4)C=C3)=CC=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 318 Related Classifications
HY-183304 Related Classifications
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