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Cat. No.: HY-W130132

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Bromotubercidin

Name: Bromotubercidin
Brand: MedChemExpress
SKU: HY-W130132
Price: 73.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Bromotubercidin is a RNA synthesis inhibitor. Bromotubercidin induces biphasic decreases in vasopressin biosynthesis and causes progressive reduction in vasopressin biosynthesis.

For research use only. We do not sell to patients.

CAS No.: 21193-80-6
Formula: C₁₁H₁₃BrN₄O₄
Molecular Weight:345.15

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Bromotubercidin Chemical Structure

CAS No.: 21193-80-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

Bromotubercidin is a RNA synthesis inhibitor. Bromotubercidin induces biphasic decreases in vasopressin biosynthesis and causes progressive reduction in vasopressin biosynthesis^[1].

All DNA/RNA Synthesis Isoforms :

All Vasopressin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	1.2 μM Compound: 1b	Tested for cytotoxicity in human foreskin fibroblasts at time of HCMV plaque enumeration Tested for cytotoxicity in human foreskin fibroblasts at time of HCMV plaque enumeration	[PMID: 8254613]
HFF	IC₅₀	4.5 μM Compound: 1n	Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) Cytotoxicity against uninfected human foreskin fibroblast(HFF cells)	[PMID: 2846837]
HFF	IC₅₀	4.5 μM Compound: Br-Tub	Cytotoxic activity against HFF cells. Cytotoxic activity against HFF cells.	[PMID: 2163454]
KB	IC₅₀	2.3 μM Compound: 1n	Cytotoxicity against human neoplastic cell line(KB cells) Cytotoxicity against human neoplastic cell line(KB cells)	[PMID: 2846837]
KB	IC₅₀	3 μM Compound: 1b	Tested for the inhibition of KB cell growth Tested for the inhibition of KB cell growth	[PMID: 8254613]
KB	IC₅₀	3 μM Compound: 5-bromotubercidin	Cytotoxicity of compound was determined by assaying cell growth in human neoplastic cell line(KB). Cytotoxicity of compound was determined by assaying cell growth in human neoplastic cell line(KB).	[PMID: 1310744]
L1210	IC₅₀	4 μM Compound: 1b	Tested for in vitro cell growth inhibition of L1210 cells Tested for in vitro cell growth inhibition of L1210 cells	[PMID: 8254613]
L1210	IC₅₀	4 μM Compound: 5-bromotubercidin	Concentration required to decrease the growth rate to 50% of control was evaluated by determining their ability to inhibit growth of L1210 cells in vitro. Concentration required to decrease the growth rate to 50% of control was evaluated by determining their ability to inhibit growth of L1210 cells in vitro.	[PMID: 1310744]
L1210	IC₅₀	4 μM Compound: Br-Tub	In vitro inhibition of L1210 cell growth to half of the control rate In vitro inhibition of L1210 cell growth to half of the control rate	[PMID: 2163454]
Neoplastic cell line	IC₅₀	2.3 μM Compound: Br-Tub	Cytotoxic activity against KB cells. Cytotoxic activity against KB cells.	[PMID: 2163454]

Chemical Information

CAS No. 21193-80-6
Appearance Solid
Molecular Weight 345.15
Formula C₁₁H₁₃BrN₄O₄
SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3C(Br)=C2)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pearson D, et al. The hypothalamo-neurohypophysial complex in organ culture: effects of metabolic inhibitors, biologic and pharmacologic agents. Endocrinology. 1975 Apr;96(4):994-1003. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Bromotubercidin

All DNA/RNA Synthesis Isoforms

All Vasopressin Receptor Isoforms