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Sulfasalazine

(Synonyms: NSC 667219)
81 Cited Publications
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Based on 81 publication(s) in Google Scholar

Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.

For research use only. We do not sell to patients.

  • Purity: 99.57%
  • CAS No.: 599-79-1
  • Formula: C18H14N4O5S
  • Molecular Weight:398.39
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Sulfasalazine Chemical Structure
    Sulfasalazine Chemical Structure
  • Experimental Validation Results for Sulfasalazine
  • Experimental Validation Results for Sulfasalazine
  • Experimental Validation Results for Sulfasalazine
  • Experimental Validation Results for Sulfasalazine
  • Experimental Validation Results for Sulfasalazine
CAS No.: 599-79-1
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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2D/3D Cell Culture and DifferentiationIn Vivo Efficacy StudyHistological Imaging/StainingWB
  • 2D/3D Cell Culture and Differentiation
  • In Vivo Efficacy Study
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  • Sulfasalazine Chemical Structure
    Sulfasalazine Chemical Structure
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    Sulfasalazine purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Dec 25.

    Customer Validation
     Sulfasalazine (SSA, 0.1–100 mM, 24 h) inhibited cell growth in parental HCCLM3 cells and the indicated clones with reconstituted expression of the WTAP S176A (left) or knock-in expression of GLS Mut (right).

  • 1/16

    Sulfasalazine purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Dec 25.

    Customer Validation
     Sulfasalazine (SAS, 100 mg/kg, i.p., 30 days) inhibited tumor growth in athymic nude mice bearing HCCLM3 cells with wildtype or WTAP S176A mutant.

  • 1/16

    Sulfasalazine purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Dec 25.

    Customer Validation
     Sulfasalazine (SAS, 100 mg/kg, i.p., 30 days) decreased GAC expression and increased 4-HE expression in athymic nude mice bearing either wildtype HCCLM3 cells or cells expressing the WTAP S176A mutant.

  • 1/16

    Sulfasalazine purchased from MedChemExpress. Usage Cited in: Mol Ther. 2021 Jul 7;29(7):2321-2334. [Abstract]

    Customer Validation
     PD-L1 expression is significantly increased after Sulfasalazine (SAS) treatment at both the protein and mRNA levels.

  • 1/16

    Sulfasalazine purchased from MedChemExpress. Usage Cited in: Cell Res. 2018 Dec;28(12):1171-1185. [Abstract]

    Customer Validation
     Melanoma A375 cells are treated with SSZ (Sulfasalazine, 125 μM) with or without FeSO4 (100 μM) for 6 h to detect the ROS level or 24 h to assess the pyroptotic features (including morphology, GSDME cleavage, and LDH release), unless specifically defined.

  • Sulfasalazine