BIMU 8
Based on 1 publication(s) in Google Scholar
BIMU 8 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.
For research use only. We do not sell to patients.
- Purity : 99.60%
- CAS No.: 134296-40-5
- Formula: C19H27ClN4O2
- Molecular Weight:378.90
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BIMU 8
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[2]|
5-HT4 Receptor 18 nM (EC50) |
In Vitro
In myenteric neurons of guinea pig ileum, BIMU 8 (0.003-0.1 μM) increases excitatory postsynaptic potentials (EPSPs) mplitude but does not change the membrane potential of any neuron[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 134296-40-5
-
Appearance Solid
-
Molecular Weight 378.90
-
Formula C19H27ClN4O2
-
Color White to off-white
-
SMILES
CN([C@](CC1)([H])C2)[C@@]1([H])C[C@@H]2NC(N3C4=CC=CC=C4N(C3=O)C(C)C)=O.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
In Vitro:
DMSO : 37.79 mg/mL (99.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (292 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. C Ghelardini, et al. Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. Life Sci. 1996;58(25):2297-309. [Content Brief]
[2]. Lucie P Pellissier, et al. Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol. 2009 Apr;75(4):982-90. [Content Brief]
[3]. H Pan , et al. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol. 1994 Feb;266(2 Pt 1):G230-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6392 mL | 13.1961 mL | 26.3922 mL | 65.9805 mL |
| 5 mM | 0.5278 mL | 2.6392 mL | 5.2784 mL | 13.1961 mL | |
| 10 mM | 0.2639 mL | 1.3196 mL | 2.6392 mL | 6.5980 mL | |
| 15 mM | 0.1759 mL | 0.8797 mL | 1.7595 mL | 4.3987 mL | |
| 20 mM | 0.1320 mL | 0.6598 mL | 1.3196 mL | 3.2990 mL | |
| 25 mM | 0.1056 mL | 0.5278 mL | 1.0557 mL | 2.6392 mL | |
| 30 mM | 0.0880 mL | 0.4399 mL | 0.8797 mL | 2.1993 mL | |
| 40 mM | 0.0660 mL | 0.3299 mL | 0.6598 mL | 1.6495 mL | |
| 50 mM | 0.0528 mL | 0.2639 mL | 0.5278 mL | 1.3196 mL | |
| 60 mM | 0.0440 mL | 0.2199 mL | 0.4399 mL | 1.0997 mL | |
| 80 mM | 0.0330 mL | 0.1650 mL | 0.3299 mL | 0.8248 mL |
BIMU 8 Related Classifications
HY-110094 Related Classifications
Powered by Bioz