Cat. No.: HY-W015883A

Fumaric acid disodium

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Fumaric acid disodium is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid disodium exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid disodium can be used in the study of pregnancy-induced hypertension.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 17013-01-3
Formula: C₄H₂Na₂O₄
Molecular Weight:160.04

Storage:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

Fumaric acid disodium Chemical Structure

CAS No.: 17013-01-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All NF-κB Isoforms :

All p38 MAPK Isoforms :

In Vitro

Fumaric acid (50 μM, 24 h) disodium inhibits p38 MAPK-dependent NF-κB signaling pathway and decreases the expression of eotaxin-1 in TNF-α-stimulated fibroblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

NIH/3T3
Concentration:

50 μM
Incubation Time:

24 h
Result:

Inhibited p38 MAPK and IκB-a phosphorylation.
Attenuated TNF-a-induced NF-κB and decreased the expression of CCR3.
Reduced the NF-κB activation induced by TRADD, TRAF2, and MEKK3.

In Vivo

Fumaric acid (10 mL/kg, intravenously injected) disodium is used to treat gestational hypertension by down-regulating the expression of KCNMB1 and TET1^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Gestational hypertension rat model^[3]
Dosage:

10 mL/kg
Administration:

i.v.
Result:

Downregulated the levels of TET1 and KCNMB1.

Chemical Information

CAS No. 17013-01-3
Appearance Solid
Molecular Weight 160.04
Formula C₄H₂Na₂O₄
Color White to off-white
SMILES

O=C(O[Na])/C=C/C(O[Na])=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Publications (4)

All Cell Proliferation/Viability AssayWBCell Imaging/StainingBio/Physico-chemical Assay

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Gut Microbes

Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer. [Abstract]

2023 Jan-Dec;15(1):2186114. PMID: 36941257
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Phytomedicine

Theabrownins improve burn-induced kidney injury by increasing the levels of guanidinoacetic acid and fumaric acid. [Abstract]

2025 May:140:156609. PMID: 40090045

Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]

Fumaric acid (12 h). MTT assays were performed to evaluate the effects of different concentrations of GAA and FA pretreatments on the viability of HK2 cells exposed to CDDP.

Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]

Fumaric acid (50 μM; 12 h). Western blot analysis was performed to assess the impacts of GAA and FA pretreatments on KIM1 protein levels in HK2 cells following exposure to H₂O₂.

Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]

Fumaric acid (50 μM; 12 h). FIGURETUNEL staining was performed to evaluate the effects of FA pretreatments on the degree of apoptosis in HK2 cells exposed to CDDP.

Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]

Fumaric acid (50 μM; 12 h). The effects of the FA pretreatments on intracellular GSH levels in HK2 cells exposed to erastin were evaluated.

Fumaric acid disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156609. [Abstract]

Fumaric acid (50 μM; 12 h). Western blotting was conducted to evaluate the effects of FA pretreatments on the levels of GPX4 in HK2 cells exposed to erastin.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (624.84 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.2484 mL

31.2422 mL

62.4844 mL

5 mM

1.2497 mL

6.2484 mL

12.4969 mL

10 mM

0.6248 mL

3.1242 mL

6.2484 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8. [Content Brief]

[2]. Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31. [Content Brief]

[3]. Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22(4):1072. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.2484 mL	31.2422 mL	62.4844 mL	156.2110 mL
	5 mM	1.2497 mL	6.2484 mL	12.4969 mL	31.2422 mL
	10 mM	0.6248 mL	3.1242 mL	6.2484 mL	15.6211 mL
	15 mM	0.4166 mL	2.0828 mL	4.1656 mL	10.4141 mL
	20 mM	0.3124 mL	1.5621 mL	3.1242 mL	7.8105 mL
	25 mM	0.2499 mL	1.2497 mL	2.4994 mL	6.2484 mL
	30 mM	0.2083 mL	1.0414 mL	2.0828 mL	5.2070 mL
	40 mM	0.1562 mL	0.7811 mL	1.5621 mL	3.9053 mL
	50 mM	0.1250 mL	0.6248 mL	1.2497 mL	3.1242 mL
	60 mM	0.1041 mL	0.5207 mL	1.0414 mL	2.6035 mL
	80 mM	0.0781 mL	0.3905 mL	0.7811 mL	1.9526 mL
	100 mM	0.0625 mL	0.3124 mL	0.6248 mL	1.5621 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Fumaric acid disodium

4 Cited Publications

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Fumaric acid disodium

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Publications Citing Use of MedChemExpress (MCE) Fumaric acid disodium

All Endogenous Metabolite Isoforms

All NF-κB Isoforms

All p38 MAPK Isoforms