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Cat. No.: HY-124482

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Mesembrenol

Mesembrenol, an alkaloid, is an AMPA receptor antagonist and a serotonin reuptake inhibitor. Mesembrenol binds to the serotonin transporter (SERT) with a K_i of 63 nM and inhibits PDE4B with an IC₅₀ of 16 μM. Mesembrenol attenuates hippocampal glutamatergic transmission and population spike amplitude. Mesembrenol can be used in research on epilepsy, anxiety, and Parkinson's disease.

For research use only. We do not sell to patients.

CAS No.: 25516-15-8
Formula: C₁₇H₂₃NO₃
Molecular Weight:289.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (294 KB)

Mesembrenol Chemical Structure

CAS No.: 25516-15-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[2]^[1]

PDE4

16 μM (IC₅₀)

AMPA Receptor

All Phosphodiesterase (PDE) Isoforms :

All iGluR Isoforms :

In Vitro

Glutamate Release or ReceptorsOthers

Glutamate Release or Receptors

Mesembrenol (17 nM; 1 h) attenuated population spike amplitudes in rat hippocampus slices and prevented the action of the AMPA receptor agonist Fluorowillardine, acting as the main compounds responsible for the AMPA receptor-mediated physiological effects^[1].

Others

Mesembrenol inhibits the serotonin transporter (SERT) with a K_i of 63 nM^[3].
Mesembrenol inhibits PDE4B with an IC₅₀ of 16 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mesembrenol (5-25 μg/mL; immersion; single 1 h exposure) does not exhibit antidepressant-like activity in the Reserpine (HY-N0480)-induced depression model in zebrafish larvae^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Human pluripotent stem cell midbrain dopaminergic neuron differentiation

Chemical Information

CAS No. 25516-15-8
Molecular Weight 289.37
Formula C₁₇H₂₃NO₃
SMILES

O[C@@H]1C=C[C@]2(CCN([C@]2(C1)[H])C)C3=CC=C(C(OC)=C3)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (294 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dimpfel W, et al. Effect of Zembrin and four of its alkaloid constituents on electric excitability of the rat hippocampus. Journal of ethnopharmacology. 2018 Sep 15;223:135-141.

[2]. Gericke J, et al. Sceletium tortuosum-derived mesembrine significantly contributes to the anxiolytic effect of Zembrin®, but its anti-depressant effect may require synergy of multiple plant constituents. Journal of ethnopharmacology. 2024 Jan 30;319(Pt 1):117113.

[3]. Krstenansky JL, et al. Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology. Journal of ethnopharmacology. 2017 Jan 04;195:10-19. [Content Brief]

[4]. Lepule K, et al. Zembrin® Mitigates Reserpine-Induced Motor Dysfunction and Oxidative Stress in Parkinson's Disease: In Vivo and In Silico Analyses. Molecules. 2026 Jul 5;31(13):2369.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Mesembrenol

All Phosphodiesterase (PDE) Isoforms

All iGluR Isoforms