SB-216641A
Based on 1 Customer Validation
SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H.
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 193611-67-5
- Formula: C28H31ClN4O4
- Molecular Weight:523.02
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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5-HT1B Receptor |
5-HT1D Receptor |
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Guinea pigs[1].
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Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.
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Administration:Intraperitoneal injection; single dose.
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Result:Significantly blocked the effects of SKF-99101H.
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Animal Model:Dogs[2].
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Dosage:559 nmol/kg.
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Administration:Intravenous injection; single dose.
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Result:Improved the gastric relaxation.
Chemical Information
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CAS No. 193611-67-5
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Appearance Solid
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Molecular Weight 523.02
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Formula C28H31ClN4O4
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Color White to off-white
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SMILES
O=C(C1=CC=C(C2=C(C)C=C(C3=NOC(C)=N3)C=C2)C=C1)NC4=CC=C(C(OCCN(C)C)=C4)OC.Cl
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Synonyms
SB-216641 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 26.15 mg/mL (50.00 mM; Need ultrasonic and warming)
DMSO : 5 mg/mL (9.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hagan JJ, et al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74. [Content Brief]
[2]. De Ponti F, et al. Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G96-104. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.9120 mL | 9.5599 mL | 19.1197 mL | 47.7993 mL |
| 5 mM | 0.3824 mL | 1.9120 mL | 3.8239 mL | 9.5599 mL | |
| H2O | 10 mM | 0.1912 mL | 0.9560 mL | 1.9120 mL | 4.7799 mL |
| 15 mM | 0.1275 mL | 0.6373 mL | 1.2746 mL | 3.1866 mL | |
| 20 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3900 mL | |
| 25 mM | 0.0765 mL | 0.3824 mL | 0.7648 mL | 1.9120 mL | |
| 30 mM | 0.0637 mL | 0.3187 mL | 0.6373 mL | 1.5933 mL | |
| 40 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1950 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SB-216641A Related Classifications
HY-103149 Related Classifications
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