Bacampicillin
Bacampicillin is an orally active semi-synthetic aminopenicillin derivative, prodrug and bactericide that is readily inactivated by β-lactamases. Bacampicillin is hydrolyzed by carboxylester hydrolases and non-specific esterases in the gastrointestinal wall and plasma to form Ampicillin (HY-B0522), and produces higher levels of Ampicillin in rodents in vivo. Bacampicillin exhibits bactericidal activity against Gram-positive and Gram-negative bacteria. Bacampicillin can be used in studies related to bacterial infections.
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- CAS No.: 50972-17-3
- Formule: C21H27N3O7S
- Masse moléculaire:465.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Bacampicillin (10-20 μg/mL; 30 min) is stable in synthetic gastric juice (pH 1.2) and phosphate buffer (pH 7.4), but undergoes extensive hydrolysis to Ampicillin (HY-B0522) in the presence of 10% human or rat serum after 30 min incubation at 37°C, with rat serum driving more complete hydrolysis than human serum[1].
Bacampicillin (100 μg/mL; up to 30 min) undergoes rapid first-order hydrolysis to Ampicillin in heparinized human blood, human plasma, and canine plasma at 37°C, with the fastest hydrolysis observed in human blood[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Bacampicillin (135 mg/kg; p.o.; single dose) produces significantly higher and longer-lasting interstitial fluid Ampicillin levels in female SPF-grade Sprague-Dawley rats with subcutaneous tissue cages compared to equimolar doses of Ampicillin[1].
Bacampicillin (135 mg/kg; p.o.; single dose) produces ampicillin concentrations in the kidney and liver tissues of female SPF-grade Sprague-Dawley rats that are 3 to 4 times those of equimolar ampicillin[1].
Bacampicillin (20 mg/kg; p.o.; single dose) exhibits 3-fold higher bioavailability than equimolar ampicillin in female beagle dogs[1].
Bacampicillin (p.o.; single dose) exhibits potent activity against a variety of bacterial infections in female NMRI mice, with better efficacy than Ampicillin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 50972-17-3
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Masse moléculaire 465.52
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Formule C21H27N3O7S
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N)C3=CC=CC=C3)=O)N1C2=O)OC(OC(OCC)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bacampicillin Related Classifications
HY-B1149 Related Classifications
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- Bacampicillin
- 50972-17-3
- Drug Derivative
- Bacterial
- Antibiotic
- gram-negative bacteria
- upper respiratory tract infections
- urinary tract infections
- uncomplicated gonorrhea
- carboxylester hydrolase
- skin and soft tissue infections
- bacterial infections
- gram-positive bacteria
- lower respiratory tract infections
- beta-lactamase
- Inhibitor
- inhibitor
- inhibit