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Decitabine

(Synonyms: 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716)
183 Cited Publications
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Based on 183 publication(s) in Google Scholar

Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity.

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  • Pureté: 99.87%
  • CAS No.: 2353-33-5
  • Formule: C8H12N4O4
  • Masse moléculaire:228.21
  • Stockage:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Decitabine Chemical Structure
    Decitabine Chemical Structure
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
  • Experimental Validation Results for Decitabine
CAS No.: 2353-33-5
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  • Decitabine Chemical Structure
    Decitabine Chemical Structure
    1/16
  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Cell. 2024 Apr 25;187(9):2288-2304.e27. [Abstract]

    Customer Validation
     SLC6A6 mRNA levels in the indicated cells treated with decitabine (1 μM for 3 days).

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2022 Mar 29;2022:2371807. [Abstract]

    Customer Validation
     The toxicity of decitabine to Y79 and WERI-RB-1 cells is detected by CCK-8 assay at different concentrations of Decitabine.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2022 Mar 29;2022:2371807. [Abstract]

    Customer Validation
     The mRNA expression of GSDME is detected using RT-PCR after treatment with different concentrations of Decitabine for 3 days (the cells were centrifuged, and decitabine is replaced every day).

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2022 Mar 29;2022:2371807. [Abstract]

    Customer Validation
     The protein level of GSDME in cells is quantitatively analysed by western blot in Y79 and WERI-RB-1 cells after Decitabine (2 nM; 3 days) treatment.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2022 Mar 29;2022:2371807. [Abstract]

    Customer Validation
     The protein level of GSDME in cells is detected using immunofluorescence in Y79 and WERI-RB-1 cells after Decitabine (2 nM; 3 days) treatment.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2021 Jul;54(7):e13072. [Abstract]

    Customer Validation
     The indicated HSCs are subjected to DNMTs inhibitor (5‐azadC, 2 μM), G9a inhibitor (UNC0642, 2 μM) and pan‐HDAC inhibitor (ITF‐2357, 100 nM) for 48 h, or EZH2 inhibitor (EPZ‐6438, 10 μM) for 72h. KLF14 expression is measured by RT‐qPCR.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2021 Jul;54(7):e13072. [Abstract]

    Customer Validation
     The indicated HSCs are subjected to DNMTs inhibitor (5‐azadC, 2 μM), G9a inhibitor (UNC0642, 2 μM) and pan‐HDAC inhibitor (ITF‐2357, 100 nM) for 48 h, or EZH2 inhibitor (EPZ‐6438, 10 μM) for 72h. KLF14 expression is measured by Western blotting analyses.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Prog Neurobiol. 2021 Jun:201:102028. [Abstract]

    Customer Validation
     The TF changes induced by DNMT3L in these cells are not affected with Decitabine (10 µM; for 24 hours) treatment in most genes tested, except NEUROD2 and NEUROG2 as shown by qRTPCR.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Oncogene. 2020 Aug;39(33):5507-5519. [Abstract]

    Customer Validation
     Quantitative real-time PCR analysis of CDH13 expression after 5 μM Decitabine treatment.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: J Invest Dermatol. 2020 Dec;140(12):2442-2454.e5. [Abstract]

    Customer Validation
     In EZH2 mutant cells, after six days of drug treatment with both GSK126 and 0.5 μM Decitabine, Western blots shows complete elimination of H3K37me3 with reductions in DNMT1A, DNMT3A, and DNMT3B.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: J Invest Dermatol. 2020 Dec;140(12):2442-2454.e5. [Abstract]

    Customer Validation
     In EZH2 mutant cells, after six days of drug treatment with both GSK126 and 0.5 μM Decitabine, Significant upregulation of RASSF5, EPAS1, ITGB2, and NDRG1 target gene expression is seen in EZH2 mutant cell lines.

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2019 Oct;78(10):1420-1429. [Abstract]

    Customer Validation
     Western blot of PPARγ from mouse chondrocytes treated with IL-1β (10 ng/mL) for 24 hours in absence or presence 5Aza of various doses (0, 1, 5 and 10 µM).

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2019 Oct;78(10):1420-1429. [Abstract]

    Customer Validation
     Western blot of PPARγ, MMP13, Aamts5, Aggrecan and Collagen2 from Sham, DMM and 5Aza-treated mouse joint tissues (0.35 mg/kg; intraperitoneal injection daily; 10 weeks).

  • 1/16

    Decitabine purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2019 Jun;143(6):2038-2051.e12. [Abstract]

    Customer Validation
     Naive CD4+ T cells are stimulated with anti-CD3/CD28 in the presence of mock stimulant or Decitabine (5-aza-29-deoxycytidine; 1 µM). Real-time PCR analysis of Il4 and Il13 mRNA after 24 hours of stimulation and IL-4 and IL-13 concentrations in culture supernatants after 72 hours of stimulation are measured.

  • Decitabine