Uridine triphosphate
Based on 4 publication(s) in Google Scholar
Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Uridine triphosphate trisodium salt) that retains the same biological activity.
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- CAS No.: 63-39-8
- Formule: C9H15N2O15P3
- Masse moléculaire:484.14
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Stockage:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
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Other In-stock Forms of Uridine triphosphate
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Uridine triphosphate
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Activité biologique
Description
IC50 & Target
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Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
0.45 μM
Compound: UTP
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Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
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[PMID: 16539385] |
| HEK293 | EC50 |
0.13 μM
Compound: UTP
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Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
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[PMID: 16539385] |
| NG108-15 | EC50 |
1.26 μM
Compound: UTP
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Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
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[PMID: 19523835] |
| NG108-15 | IC50 |
1.51 μM
Compound: UTP
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Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
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[PMID: 19523835] |
In Vitro
Uridine triphosphate enhances the migration and wound repair of RT4-D6P2T cells by activating the P2Y2 receptor and increasing the activation and expression of extracellular MMP-2[2].
Uridine triphosphate induces MAPK phosphorylation in a biphasic manner. It causes early transient phosphorylation within 5 minutes after treatment, and late persistent phosphorylation occurs 6 hours later, lasting for up to 24 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RT4-D6P2T cells
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Concentration:250 µM
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Incubation Time:5 min, 45 min, 2 h, 6 h, 12 h, 24 h, 48 h
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Result:Induces biphasic MAPK phosphorylation.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (250-300 g; 2-3 months) with myocardial infarction (MI)[3]
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Dosage:0.44 µg/kg 30 min before MI, and 4.4 µg/kg i.v. 24 h prior to MI.
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Administration:i.v.; once
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Result:Reduced infarct size and improves rat heart function after myocardial infarct.
Chemical Information
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CAS No. 63-39-8
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Appearance Solid
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Masse moléculaire 484.14
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Formule C9H15N2O15P3
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Color White to off-white
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SMILES
O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)O2)NC(C=C1)=O
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Synonyms
UTP; Uridine 5'-triphosphate
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
Life Sci
2023 Sep 1:328:121896. PMID: 37385371 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559
Solvant et solubilité
In Vitro:
H2O : ≥ 150 mg/mL (309.83 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (206.55 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6. [Content Brief]
[2]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998. [Content Brief]
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.0655 mL | 10.3276 mL | 20.6552 mL | 51.6380 mL |
| 5 mM | 0.4131 mL | 2.0655 mL | 4.1310 mL | 10.3276 mL | |
| 10 mM | 0.2066 mL | 1.0328 mL | 2.0655 mL | 5.1638 mL | |
| 15 mM | 0.1377 mL | 0.6885 mL | 1.3770 mL | 3.4425 mL | |
| 20 mM | 0.1033 mL | 0.5164 mL | 1.0328 mL | 2.5819 mL | |
| 25 mM | 0.0826 mL | 0.4131 mL | 0.8262 mL | 2.0655 mL | |
| 30 mM | 0.0689 mL | 0.3443 mL | 0.6885 mL | 1.7213 mL | |
| 40 mM | 0.0516 mL | 0.2582 mL | 0.5164 mL | 1.2909 mL | |
| 50 mM | 0.0413 mL | 0.2066 mL | 0.4131 mL | 1.0328 mL | |
| 60 mM | 0.0344 mL | 0.1721 mL | 0.3443 mL | 0.8606 mL | |
| 80 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6455 mL | |
| 100 mM | 0.0207 mL | 0.1033 mL | 0.2066 mL | 0.5164 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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