ADX68692
ADX68692 is an orally active negative allosteric modulators of follicle-stimulating hormone receptor with a log IC50 of -5.71. ADX68692 can inhibit hCG-induced cAMP production and s ß-arrestin 2 recruitment in HEK293 cells. ADX68692 exhibits a partial effect in both mLTC-1 and primary rat Leydig cells. ADX68692 inhibits FSHR-promoted cAMP, progesterone and estradiol production. ADX68692 can reduce the number of oocytes recovered from the ampullae.
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- CAS No.: 1067191-08-5
- Formule: C24H23N3O3
- Masse moléculaire:401.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Chemical Information
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CAS No. 1067191-08-5
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Masse moléculaire 401.46
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Formule C24H23N3O3
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SMILES
CC(C(C(C1=CN=CC=C1)=C2)=CC=C2NC(C3=CC=C(OC)C(OC)=C3)=O)(C#N)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ayoub MA, et al., Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis. Mol Cell Endocrinol. 2016 Nov 15;436:10-22. [Content Brief]
[2]. Dias JA, et al., Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor. Biol Reprod. 2014 Jan 30;90(1):19. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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