country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183304

Copy Link Print Information

Anticancer agent 318

Anticancer agent 318 (Compound 8 (6)) is a selective anticancer agent. Anticancer agent 318 can be metabolized by CYP1A1, CYP1A2 and CYP1B1. After bioactivation, Anticancer agent 318 exerts antiproliferative activity in breast cancer cells expressing CYP1. Anticancer agent 318 can be used in the research of breast cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2482789-24-0
Formule: C₂₀H₁₇NO₄
Masse moléculaire:335.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 318 Chemical Structure

CAS No.: 2482789-24-0

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

CYP1A1

CYP1A2

CYP1B1

Voir tous les produits spécifiques à Isoform Cytochrome P450 :

In Vitro

The anticancer agent 318 potently inhibits the proliferation of CYP1-expressing breast cancer cell lines MDA-MB-468 (IC₅₀ = 0.08 μM) and TCDD-induced MCF-7 (IC₅₀ = 0.006 μM), shows no toxicity toward non-tumorigenic MCF-10A cells (IC₅₀ = 100 μM), and its activity depends on CYP1-mediated bioactivation^[1].
The anticancer agent 318 (0-30 min) is metabolized by CYP1A1, CYP1A2 and CYP1B1 (but not CYP3A4) enzymes, producing four distinct metabolites via demethylenation, O-demethylation and hydroxylation reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2482789-24-0
Masse moléculaire 335.35
Formule C₂₀H₁₇NO₄
SMILES

COC1=CC(OC)=C(C=C1)C2=CC(C3=CC4=C(OCO4)C=C3)=CC=N2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ruparelia K, et al. CYP1-bioactivated 2,4-diaryl-substituted pyridine analogues with remarkable activity in a breast cancer in vitro model. Bioorg Med Chem Lett. 2026;137:130648. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Anticancer agent 318

Voir tous les produits spécifiques à Isoform Cytochrome P450

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Anticancer agent 318 Related Classifications

HY-183304 Related Classifications