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Cat. No.: HY-123886

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Aranciamycin

Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC₅₀3.7*10_-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells .

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CAS No.: 72389-06-1
Formule: C₂₇H₂₈O₁₂
Masse moléculaire:544.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Aranciamycin Chemical Structure

CAS No.: 72389-06-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Aranciamycin (Compound 1) is an anthracycline antibiotic with collagenase inhibitory activity (IC₅₀3.7*10_-7M). Aranciamycin can be used to inhibit DNA synthesis in tumor cells ^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.7 μM Compound: 7	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 38412432]
HeLa	IC₅₀	2.7 μM Compound: 3	Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay	[PMID: 20192240]
HepG2	IC₅₀	18 μM Compound: 4	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]
HL-60	IC₅₀	4.1 μM Compound: 3	Cytotoxicity against human HL60 cells after 48 hrs by WST8 assay Cytotoxicity against human HL60 cells after 48 hrs by WST8 assay	[PMID: 20192240]
KB 3-1	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human KB-3-1 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human KB-3-1 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]
NCI-H460	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]
PC-3	IC₅₀	1.1 μM Compound: 7	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 38412432]
SW-620	IC₅₀	>30 μM Compound: 4	Cytotoxicity against human SW620 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SW620 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 25789410]

Chemical Information

CAS No. 72389-06-1
Masse moléculaire 544.50
Formule C₂₇H₂₈O₁₂
SMILES

O=C1[C@@](C)(O)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)OC)C(C(O)=C3C(C4=C5C=CC=C4O)=O)=C1C=C3C5=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bols M, et al. Inhibition of collagenase by aranciamycin and aranciamycin derivatives. J Med Chem. 1992 Jul 24;35(15):2768-71. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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