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Cat. No.: HY-186016

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Arg-PEG1-Dasa

Arg-PEG1-Dasa is a mini-PROTAC targeting BCR-ABL. Arg-PEG1-Dasa induces BCR-ABL degradation (EC₅₀ = 0.85 nM) and shows antiproliferative activity in K562 cells (IC₅₀ = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research.
(Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0455); Black: linker).

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CAS No.: 3037776-67-0
Formule: C₃₃H₄₇ClN₁₂O₅S
Masse moléculaire:759.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Arg-PEG1-Dasa Chemical Structure

CAS No.: 3037776-67-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Arg-PEG1-Dasa is a mini-PROTAC targeting BCR-ABL. Arg-PEG1-Dasa induces BCR-ABL degradation (EC₅₀ = 0.85 nM) and shows antiproliferative activity in K562 cells (IC₅₀ = 0.36 nM). Arg-PEG1-Dasa can be used for chronic myeloid leukemia research^[1]. (Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0455); Black: linker).

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Bcr-Abl :

Abl
Bcr-Abl

Chemical Information

CAS No. 3037776-67-0
Masse moléculaire 759.32
Formule C₃₃H₄₇ClN₁₂O₅S
SMILES

CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCOC(CCOCCNC([C@@H](N)CCCNC(N)=N)=O)=O)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Arg-PEG1-Dasa

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Bcr-Abl

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Arg-PEG1-Dasa Related Classifications

HY-186016 Related Classifications