Cefquinome
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Cefquinome is a broad-spectrum cephem antibiotic that has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococci, Streptococci, Pseudomonas, and Enterobacteriaceae.
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- CAS No.: 84957-30-2
- Formule: C23H24N6O5S2
- Masse moléculaire:528.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Cefquinome binds to penicillin-binding proteins (PBPs), thereby inhibiting the synthesis of bacterial cell walls[3].
Cefquinome inhibits methicillin susceptible S. aureus, Streptococcus spp., Enterococci, E. coli, Salmonella spp., Klebsiella spp., S. marcescens, Enterobacter spp., Citrobacter spp., P. mirabilis, Indole-positive Proteus spp., P. aeruginosa with MICs of 0.006-6.25 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:K. pneumoniae-infected rats models[2]
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Dosage:12.5 mg/kg
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Administration:tail vein injection, single dose
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Result:Reduced lung inflammatory cell infiltration and lung tissue damage.
Inhibited the expression of inflammatory factors TNF-α, IL-1β and IL-8, promoted the expression of anti-inflammatory factors IL-4, IL-10 and IL-13.
Chemical Information
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CAS No. 84957-30-2
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Masse moléculaire 528.60
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Formule C23H24N6O5S2
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SMILES
O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@@]3([H])SCC(C[N+]4=C5CCCCC5=CC=C4)=C(C([O-])=O)N13
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Chin NX, et al. In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics. Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):331-7. [Content Brief]
[2]. Qu S, et al., Cefquinome-loaded microsphere formulations against Klebsiella pneumonia infection during experimental infections. Drug Deliv. 2018 Nov;25(1):909-915. [Content Brief]
[3]. Limbert M, et al., Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1991 Jan;35(1):14-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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