Cephaloridine
Cephaloridine is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity.
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- CAS No.: 50-59-9
- Formule: C19H17N3O4S2
- Masse moléculaire:415.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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β-lactam |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
1250 μM
Compound: Cephaloridine
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TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells
TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells
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[PMID: 10929807] |
| HeLa | IC50 |
230 μM
Compound: Cephaloridine
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TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM) in OCTN2-expressing HeLa cells
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.02 uM) in OCTN2-expressing HeLa cells
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[PMID: 10636865] |
Cephaloridine can inhibit Staphylococcus aureus penicillin-sensitive strains, penicillin-resistant strains, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium diphtheriae, Clostridium septicum, and so on, with MICs of 0.05-1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits and monkeys[2]
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Dosage:50, 100, 200 and 500 mg/kg
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Administration:i.m.
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Result:Resulted in marked alteration in renal function and necrosis of proximal tubules at 200 and 500 mg/kg.
Did not appear to cause renal injury at 50 and 100 mg/kg.
Chemical Information
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CAS No. 50-59-9
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Masse moléculaire 415.49
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Formule C19H17N3O4S2
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SMILES
O=C(C(N12)=C(C[N+]3=CC=CC=C3)CS[C@]2([H])[C@H](NC(CC4=CC=CS4)=O)C1=O)[O-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. P. W. Muggleton, et al. Laboratory Evaluation of a New Antibiotic-Cephaloridine (Ceporin). Br Med J. 1964 Nov 14;2(5419):1234-7. [Content Brief]
[2]. Perkins RL, et al. Cephaloridine and cephalothin: comparative studies of potential nephrotoxicity. J Lab Clin Med. 1968 Jan;71(1):75-84. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cephaloridine Related Classifications
HY-B2072 Related Classifications
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