EF-4-177
EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC50 of 87 nM. EF-4-177 can disrupt spermatogenesis.
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- CAS No.: 2891574-93-7
- Formule: C18H14F5N3O2S
- Masse moléculaire:431.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK2/cyclinE 87 nM (IC50) |
Chemical Information
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CAS No. 2891574-93-7
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Masse moléculaire 431.38
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Formule C18H14F5N3O2S
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SMILES
N#CC1=CC2=C(C(CCNC3=C(C=C(C=C3)S(F)(F)(F)(F)F)C(O)=O)=CN2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Faber EB, et al. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023;66(3):1928-1940. [Content Brief]
[2]. Huang Y, et al. Targeting cyclin-dependent kinases: From pocket specificity to drug selectivity. Eur J Med Chem. Published online May 29, 2024. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EF-4-177 Related Classifications
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