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Cat. No.: HY-164924

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ERD-12310A

ERD-12310A is a PROTAC targeting Estrogen Receptor α (ERα) with a ED₅₀ value of 47 pM. ERD-12310A has oral activity. ERD-12310A can be used in the research of ER⁺ breast cancer.
(Pink: ERα ligand (HY-164925); Blue: Cereblon ligand (HY-168055); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3026007-23-5
Formule: C₅₁H₅₆N₄O₆
Masse moléculaire:821.01

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

ERD-12310A Chemical Structure

CAS No.: 3026007-23-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

ERD-12310A is a PROTAC targeting Estrogen Receptor α (ERα) with a ED₅₀ value of 47 pM. ERD-12310A has oral activity. ERD-12310A can be used in the research of ER⁺ breast cancer^[1]. (Pink: ERα ligand (HY-164925); Blue: Cereblon ligand (HY-168055); Black: linker).

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Chemical Information

CAS No. 3026007-23-5
Masse moléculaire 821.01
Formule C₅₁H₅₆N₄O₆
SMILES

O=C(N1)[C@H](CCC1=O)N(C2=O)CC3=C2C=CC4=C3OCC45CCN(CC5)C[C@H]6COC7(CC6)CCN(CC7)C8=CC=C(C=C8)[C@H]9[C@H](CCC%10=C9C=CC(O)=C%10)C%11=CC=CC=C%11
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Rohan Kalyan Rej, et al. Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα). J Med Chem. 2024 Nov 25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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ERD-12310A

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ERD-12310A Related Classifications

HY-164924 Related Classifications