F-14512
Based on 1 Customer Validation
F-14512 is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 can be used to study breast cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.04%
- CAS No.: 866874-63-7
- Formule: C33H47N5O8
- Masse moléculaire:641.75
-
Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Anti-Cancer Compound Library
HY-L025
-
Clinical Compound Library
HY-L026
-
Anti-Aging Compound Library
HY-L034
-
Drug Repurposing Compound Library
HY-L035
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Lung Cancer Compound Library
HY-L075
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Voir tous les produits spécifiques à Isoform Topoisomerase
MoreVoir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
F-14512 (0.001-100 μM) enters the cell through the polyamine transport system, in CHO cells with normal PTS, the IC50 is 0.12 μM, while in CHO-MG cells with defective PTS, the IC50 is 8.7 μM[1].
F-14512 (72 h) demonstrates high potency in multiple human cell lines (median IC50 = 0.18 μM) and is particularly effective against cell lines such as MX-1, LOX-IMV1, and HL-60[1].
F-14512 (1-100 μM, 1-24 h) induces DNA damage in A549 cells and exhibited stronger cytotoxicity in xrs6 cells with defective DNA repair[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:MX-1 human breast cancer xenograft model established in homozygous female athymic nude mice[1]
-
Dosage:0.16, 0.32, 0.63, 1.25 mg/kg
-
Administration:Intraperitoneal injection (i.p.), once daily for 2 weeks
-
Result:Led to tumor regression dose-dependently.
Chemical Information
-
CAS No. 866874-63-7
-
Appearance Solid
-
Masse moléculaire 641.75
-
Formule C33H47N5O8
-
Color White to off-white
-
SMILES
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](NC(CNCCCNCCCCNCCCN)=O)[C@@]2([H])CO1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 125 mg/mL (194.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5582 mL | 7.7912 mL | 15.5824 mL | 38.9560 mL |
| 5 mM | 0.3116 mL | 1.5582 mL | 3.1165 mL | 7.7912 mL | |
| 10 mM | 0.1558 mL | 0.7791 mL | 1.5582 mL | 3.8956 mL | |
| 15 mM | 0.1039 mL | 0.5194 mL | 1.0388 mL | 2.5971 mL | |
| 20 mM | 0.0779 mL | 0.3896 mL | 0.7791 mL | 1.9478 mL | |
| 25 mM | 0.0623 mL | 0.3116 mL | 0.6233 mL | 1.5582 mL | |
| 30 mM | 0.0519 mL | 0.2597 mL | 0.5194 mL | 1.2985 mL | |
| 40 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9739 mL | |
| 50 mM | 0.0312 mL | 0.1558 mL | 0.3116 mL | 0.7791 mL | |
| 60 mM | 0.0260 mL | 0.1299 mL | 0.2597 mL | 0.6493 mL | |
| 80 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4869 mL | |
| 100 mM | 0.0156 mL | 0.0779 mL | 0.1558 mL | 0.3896 mL |
F-14512 Related Classifications
HY-106031 Related Classifications
Powered by Bioz