ITGAM - integrin subunit alpha M Gene
Also Known as CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Species: Homo sapiens
About ITGAM
This gene has 8 transcripts (splice variants), 126 orthologues, 17 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 72.3), appendix (RPKM 14.6) and 6 other tissues.
Summary
This gene encodes the Integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha Integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific Integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 Integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
ITGAM Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000632.4 | NP_000623.2 | integrin alpha-M isoform 2 precursor |
| NM_001145808.2 | NP_001139280.1 | integrin alpha-M isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables heat shock protein binding |
IPI
IPI: Inferred from physical interaction
|
12496435 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12208882 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in cell-matrix adhesion |
IDA
IDA: Inferred from direct assay
|
18083624 | GOA |
| involved in ectodermal cell differentiation |
IEP
IEP: Inferred from expression pattern
|
23154389 | GOA |
| involved in positive regulation of neutrophil degranulation |
IGI
IGI: Inferred from genetic interaction
|
21193407 | GOA |
| involved in positive regulation of superoxide anion generation |
IGI
IGI: Inferred from genetic interaction
|
21193407 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
19234460 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
25645918 | GOA |
| part of integrin alphaM-beta2 complex |
IPI
IPI: Inferred from physical interaction
|
18083624 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
28807980 | GOA |
| located in plasma membrane raft |
IDA
IDA: Inferred from direct assay
|
21193407 | GOA |
ITGAM Protein Structure
VWA: von Willebrand factor type A domain (150 - 328)
FG-GAP: FG-GAP repeat (520 - 555)
Integrin_alpha2: Integrin alpha (614 - 1001)
Integrin_alpha: Integrin alpha cytoplasmic region (1129 - 1143)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1152 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
integrin alpha-M |
|
ITGAM Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
ITGAM | P11215 | PGRMC2 | Homo sapiens | O15173 | 32296183 | |
|
Intra
|
ITGAM | P11215 | PGRMC2 | Homo sapiens | O15173 | 32296183 | |
|
Intra
|
ITGAM | P11215 | REEP2 | Homo sapiens | Q9BRK0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | REEP2 | Homo sapiens | Q9BRK0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | REEP2 | Homo sapiens | Q9BRK0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM229B | Homo sapiens | Q8NBD8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM229B | Homo sapiens | Q8NBD8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM229B | Homo sapiens | Q8NBD8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
ITGAM | P11215 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
ITGAM | P11215 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SCN3B | Homo sapiens | Q9NY72 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SCN3B | Homo sapiens | Q9NY72 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SCN3B | Homo sapiens | Q9NY72 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CLRN1 | Homo sapiens | P58418 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CLRN1 | Homo sapiens | P58418 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CLRN1 | Homo sapiens | P58418 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GJA8 | Homo sapiens | P48165 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GJB1 | Homo sapiens | P08034 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GJB1 | Homo sapiens | P08034 | 32296183 | |
|
Intra
|
ITGAM | P11215 | PIGP | Homo sapiens | P57054 | 32296183 | |
|
Intra
|
ITGAM | P11215 | PIGP | Homo sapiens | P57054 | 32296183 | |
|
Intra
|
ITGAM | P11215 | PIGP | Homo sapiens | P57054 | 32296183 | |
|
Intra
|
ITGAM | P11215 | DKK4 | Homo sapiens | Q9UBT3 | 32296183 | |
|
Intra
|
ITGAM | P11215 | DKK4 | Homo sapiens | Q9UBT3 | 32296183 | |
|
Intra
|
ITGAM | P11215 | DKK4 | Homo sapiens | Q9UBT3 | 32296183 | |
|
Intra
|
ITGAM | P11215 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
ITGAM | P11215 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
ITGAM | P11215 | HSD17B13 | Homo sapiens | Q7Z5P4 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GPR42 | Homo sapiens | O15529 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SLC10A6 | Homo sapiens | Q3KNW5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM52B | Homo sapiens | Q4KMG9 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CERS4 | Homo sapiens | Q9HA82 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CERS4 | Homo sapiens | Q9HA82 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CERS4 | Homo sapiens | Q9HA82 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ABHD16A | Homo sapiens | O95870 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ABHD16A | Homo sapiens | O95870 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GORAB | Homo sapiens | Q5T7V8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GORAB | Homo sapiens | Q5T7V8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | GORAB | Homo sapiens | Q5T7V8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | PTN | Homo sapiens | P21246 | 28939773 | |
|
Intra
|
ITGAM | P11215 | PTN | Homo sapiens | P21246 | 28939773 | |
|
Intra
|
ITGAM | P11215 | PTN | Homo sapiens | P21246 | 28939773 | |
|
Intra
|
ITGAM | P11215 | MRM1 | Homo sapiens | Q6IN84 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MRM1 | Homo sapiens | Q6IN84 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CREB3L1 | Homo sapiens | Q96BA8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
ITGAM | P11215 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
ITGAM | P11215 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
ITGAM | P11215 | REEP4 | Homo sapiens | Q9H6H4 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
ITGAM | P11215 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
ITGAM | P11215 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SYT2 | Homo sapiens | Q8N9I0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SYT2 | Homo sapiens | Q8N9I0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | SYT2 | Homo sapiens | Q8N9I0 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
ITGAM | P11215 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
ITGAM | P11215 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
ITGAM | P11215 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 |
ITGAM Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P83690 | CD11b Antibody (YA3423) | WB, IHC-P, ICC/IF, IP, FC | Human |
| HY-P84054 | CD11b Antibody (YA3751) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84054A | CD11b Antibody (YA3751)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84956 | CD11b Antibody (YA4648) | ||
| HY-P86309 | CD11b Antibody (YA6001) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Systemic Lupus Erythematosus 6 |
|
|
| Shwartzman Phenomenon |
|
|
| Systemic Lupus Erythematosus |
|
|
| Granulocytopenia |
|
|
| Lupus Erythematosus |
|
|
| Monocytic Leukemia |
|
|
| Peritonitis |
|
|
| Pulmonary Sarcoidosis |
|
|
| Venous Insufficiency |
|
|
| Vasculitis |
|
|
| Neutropenia |
|
|
| Leukocyte Adhesion Deficiency, Type I |
|
|
| Pneumonia |
|
|
| Asthma |
|
|
| Bacterial Infectious Disease |
|
|
| Cohen Syndrome |
|
|
| Essential Thrombocythemia |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Leishmaniasis |
|
|
| Gastritis |
|
|
| Acute Myocardial Infarction |
|
|
| Vascular Disease |
|
|
| Pre-Eclampsia |
|
|
| Adult Respiratory Distress Syndrome |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Myelofibrosis |
|
|
| Listeriosis |
|
|
| Myocardial Infarction |
|
|
| Common Variable Immunodeficiency |
|
|
| Glycogen Storage Disease |
|
|
| Autoimmune Myocarditis |
|
|
| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
|
| Autoimmune Uveitis |
|
|
| Diabetes Mellitus |
|
|
| Cystic Fibrosis |
|
|
| Rheumatoid Arthritis |
|
|
| Interstitial Lung Disease |
|
|
| Heart Disease |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Bacterial Sepsis |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Inflammatory Bowel Disease 16 |
|
|
| Combined Immunodeficiency |
|
|
| Thrombocytopenia |
|
|
| Inflammatory Bowel Disease |
|
|
| Parasitic Helminthiasis Infectious Disease |
|
|
| Bacterial Pneumonia |
|
|
| Salmonellosis |
|
|
| Sarcoidosis 1 |
|
|
| Tibial Nerve Palsy |
|
|
| Silo Filler'S Disease |
|
|
| Bronchial Disease |
|
|
| Leukocyte Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Demyelinating Disease |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Bone Inflammation Disease |
|
|
| Immune Deficiency Disease |
|
|
| Dermatitis, Atopic |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Colorectal Cancer |
|
|
| Crohn'S Disease |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Colonic Benign Neoplasm |
|
|
| Myeloma, Multiple |
|
|
| Breast Adenocarcinoma |
|
|
| Leukemia, Acute Myeloid |
|
|
| Hypertension, Essential |
|
|
| Skin Disease |
|
|
| Connective Tissue Disease |
|
|
| Nervous System Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Eye Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | ITGAM | VGNC | VGNC:99519 |
| Bos taurus | ITGAM | VGNC | VGNC:55056 |
| Canis familiaris | ITGAM | VGNC | VGNC:42133 |
| Rattus norvegicus | ITGAM | RGD | RGD:2926 |
| Mus musculus | ITGAM | MGD | MGI:96607 |
| Others | ITGAM | NCBI |