HJC0123
Based on 1 Customer Validation
HJC0123 is a STAT3 inhibitor. HJC0123 inhibits the proliferation of hepatic stellate cells and induces cell cycle arrest and apoptosis. HJC0123 reduces the phosphorylation, nuclear translocation and transcriptional activities of STAT3, increases the production of IL-6, inhibits the phosphorylation of Smad2/3 and down-regulates SOCS3. HJC0123 can be used in the study of liver fibrosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.06%
- CAS No.: 1430420-02-2
- Formule: C24H16N2O3S
- Masse moléculaire:412.46
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
STAT3 |
IL-6 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ASPC1 | IC50 |
1.25 μM
Compound: 5, HJC0123
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CYtotoxicity against human AsPC1 cells by MTS assay
CYtotoxicity against human AsPC1 cells by MTS assay
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[PMID: 23416191] |
| MCF7 | IC50 |
0.1 μM
Compound: 5, HJC0123
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CYtotoxicity against ER-positive human MCF7 cells by MTS assay
CYtotoxicity against ER-positive human MCF7 cells by MTS assay
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[PMID: 23416191] |
| MDA-MB-231 | IC50 |
0.29 μM
Compound: 5, HJC0123
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CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
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[PMID: 23416191] |
| PANC-1 | IC50 |
0.26 μM
Compound: 5, HJC0123
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CYtotoxicity against human PANC1 cells by MTS assay
CYtotoxicity against human PANC1 cells by MTS assay
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[PMID: 23416191] |
Chemical Information
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CAS No. 1430420-02-2
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Appearance Solid
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Masse moléculaire 412.46
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Formule C24H16N2O3S
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC=C(C2=C1)C=CS2(=O)=O)C3=CC(C4=CC=CC=C4)=NC5=CC=CC=C35
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (121.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4245 mL | 12.1224 mL | 24.2448 mL | 60.6119 mL |
| 5 mM | 0.4849 mL | 2.4245 mL | 4.8490 mL | 12.1224 mL | |
| 10 mM | 0.2424 mL | 1.2122 mL | 2.4245 mL | 6.0612 mL | |
| 15 mM | 0.1616 mL | 0.8082 mL | 1.6163 mL | 4.0408 mL | |
| 20 mM | 0.1212 mL | 0.6061 mL | 1.2122 mL | 3.0306 mL | |
| 25 mM | 0.0970 mL | 0.4849 mL | 0.9698 mL | 2.4245 mL | |
| 30 mM | 0.0808 mL | 0.4041 mL | 0.8082 mL | 2.0204 mL | |
| 40 mM | 0.0606 mL | 0.3031 mL | 0.6061 mL | 1.5153 mL | |
| 50 mM | 0.0485 mL | 0.2424 mL | 0.4849 mL | 1.2122 mL | |
| 60 mM | 0.0404 mL | 0.2020 mL | 0.4041 mL | 1.0102 mL | |
| 80 mM | 0.0303 mL | 0.1515 mL | 0.3031 mL | 0.7576 mL | |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2424 mL | 0.6061 mL |
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