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Cat. No.: HY-150181

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IBE-667

IBE-667 is a LFA-1 integrin agonist with a K_d value of 52 nM. IBE-667 increases the stability of the open conformation of LFA-1 and enhances its affinity for ICAM-1. IBE-667 can be used in studies related to leukocyte adhesion deficiency.

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CAS No.: 1609659-32-6
Formule: C₂₅H₂₅N₅O₂
Masse moléculaire:427.51

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IBE-667 Chemical Structure

CAS No.: 1609659-32-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Description

IC₅₀ & Target

^[1]

αLβ2

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In Vitro

IBE-667 binds directly to purified LFA-1 I domain with a K_d of 52 nM^[1].
IBE-667 acts as an agonist to enhance binding between purified LFA-1 I domain and soluble ICAM-1, with a dissociation constant of 76 nM for the ternary complex^[1].
IBE-667 (1-1000 μM) dose-dependently enhances soluble ICAM-1 binding to in vitro activated primary human T-cells via an LFA-1-dependent mechanism^[1].
IBE-667 (0-120 μM) dose-dependently induces aggregation of in vitro activated primary human T-cells via an LFA-1-dependent mechanism^[1].
IBE-667 acts as an agonist for αₗβ₂ integrin (LFA-1) on activated T-cells, enhancing ICAM-1 binding via allosteric interaction with the αₗ domain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1609659-32-6
Masse moléculaire 427.51
Formule C₂₅H₂₅N₅O₂
SMILES

O=C(NC)C1=CC=C(C=C1)N2N=C(C=3C=CC(=CC3)C(=O)NCCCN)C=4C=CC=CC42
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hintersteiner M, et al. Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. Angewandte Chemie (International ed. in English). 2014 Apr 22;53(17):4322-6.

[2]. Tolomelli A, et al. Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators. Cancers. 2017 Jul 05;9(7):78.

[3]. Abdullahi M, et al. Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation. Biotechnology letters. 2017 Dec;39(12):1843-1851.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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IBE-667

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Activité biologique

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IC50 & Target

In Vitro

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IBE-667 Related Classifications

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