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Cat. No.: HY-147196

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KB03-SLF

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12^NLS. KB03-SLF fails to degrade nuclear-localized FKBP12^NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12^NLS in a manner similar to KB02-SLF (HY-129610).
(Pink: FKBP51 and FKBP12 ligand (HY-114872); Blue: Cereblon ligand (HY-169968); Black: linker (HY-W040168)).

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CAS No.: 2384184-42-1
Formule: C₅₀H₆₃ClF₃N₅O₁₂
Masse moléculaire:1018.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KB03-SLF Chemical Structure

CAS No.: 2384184-42-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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Classifications
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Activité biologique

Description

KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12^NLS. KB03-SLF fails to degrade nuclear-localized FKBP12^NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12^NLS in a manner similar to KB02-SLF (HY-129610)^[1]. (Pink: FKBP51 and FKBP12 ligand (HY-114872); Blue: Cereblon ligand (HY-169968); Black: linker (HY-W040168)).

IC₅₀ & Target

^[1]

FKBP12

Cereblon

Voir tous les produits spécifiques à Isoform PROTACs :

In Vitro

KB03-SLF (2 µM; 8-24 h) does not support DCAF16-mediated degradation of nuclear-localized FLAG-FKBP12_NLS in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Western Blot Analysis^[1]

View Protocol

Cell Line:

HEK293T cells stably expressing nuclear-localized FLAG-FKBP12_NLS
Concentration:

5 µM
Incubation Time:

2 h
Result:

Did not promote degradation of nuclear-localized FLAG-FKBP12_NLS.
Did not induce KB02-SLF-dependent enrichment of DCAF16 with FLAG-FKBP12_NLS in co-immunoprecipitation experiments.

Chemical Information

CAS No. 2384184-42-1
Masse moléculaire 1018.51
Formule C₅₀H₆₃ClF₃N₅O₁₂
SMILES

O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@@H](C2=CC(NC(CCOCCOCCNC(CCNC(C3=CC(NC(CCl)=O)=CC(C(F)(F)F)=C3)=O)=O)=O)=CC=C2)CCC4=CC(OC)=C(C=C4)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature chemical biology. 2019 Jul;15(7):737-746. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
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KB03-SLF

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

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Calculators

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KB03-SLF Related Classifications

HY-147196 Related Classifications

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