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Cat. No.: HY-172924

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NLX-266

NLX-266 is an orally active ERK1/2-biased 5-HT_1A receptor agonist. NLX-266 can be used in the study of Parkinson's disease.

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CAS No.: 2170564-20-0
Formule: C₂₀H₂₁ClF₃N₃O₂
Masse moléculaire:427.85

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

NLX-266 Chemical Structure

CAS No.: 2170564-20-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Description
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Chemical Information
Protocole (1)
Pureté et documentation
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Description

NLX-266 is an orally active ERK1/2-biased 5-HT_1A receptor agonist. NLX-266 can be used in the study of Parkinson's disease^[1].

IC₅₀ & Target

5-HT_1A Receptor

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Chemical Information

CAS No. 2170564-20-0
Masse moléculaire 427.85
Formule C₂₀H₂₁ClF₃N₃O₂
SMILES

O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC(F)=C3)(F)CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sniecikowska J, et al. Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity. J Med Chem. 2025 May 8;68(9):9706-9722. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Pureté et documentation
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NLX-266

Voir tous les produits spécifiques à Isoform 5-HT Receptor

Activité biologique

Description

IC50 & Target

Chemical Information

Protocole

Pureté et documentation

Références

Calculators

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NLX-266 Related Classifications

HY-172924 Related Classifications

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