PM54-1
PM54 is an antitumor agent with activity across multiple cancer types. PM54 acts as a transcription and WNT/β-catenin signaling pathway inhibitor. PM54 suppresses oncogenic transcriptional programs, and key malignant pathways, while inducing DNA double-strand breaks, S-phase cell cycle arrest and apoptosis. PM54 enhances innate immune recognition, remodels the tumor microenvironment. PM54 exhibits antitumor activity as monotherapy or in combination in xenograft models. PM54 is applicable to research on various cancers and advanced solid tumors.
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- CAS No.: 2248127-86-6
- Formule: C41H43N3O11S
- Masse moléculaire:785.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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mTOR |
PM54 (50 nM; 6 h) induces a conserved pan-cancer transcriptional repression program targeting cell cycle, chromatin regulation, and DNA repair in 32 diverse cancer cell lines, with primed responders (characterized by strong suppression of MYC, mTOR, cell cycle, and DNA repair pathways, often with intact TP53 function) exhibiting a more robust transcriptomic response than adaptive responders[1].
PM54 (6-18 h) inhibits WNT/β-catenin-driven transcription in gastric cancer cell lines, reducing activity by ~40% at 6 h and >70% at 18 h[2].
PM54 exhibits strong synergy with 5-fluorouracil in HGC-27 and Hs746T diffuse-type gastric cancer cell lines, and with Cisplatin (HY-17394) in HGC-27 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PM54 (1.2 mg/kg; i.v.; once weekly; 16 days) exhibits strong antitumor activity in soft tissue sarcoma xenograft models, with the most significant effect in the STS134 model where it reduces tumor volume to 76% of baseline[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2248127-86-6
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Masse moléculaire 785.86
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Formule C41H43N3O11S
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SMILES
CC(C1=C2OCO1)=C(OC(C)=O)C3=C2[C@H](CO4)N([C@@H](O)C5N(C)C6C7=C(C=C(C)C(OC)=C7O)C5)[C@@]6([H])[C@@H]3SC[C@](C8=C9C%10=CC=CC=C%10O8)(N[C@H](CO)C9)C4=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PM54-1 Related Classifications
HY-183631 Related Classifications
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