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Cat. No.: HY-170792

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PRMT5-IN-48

PRMT5-IN-48 (compound D3) is an orally effective PRMT5 inhibitor (IC₅₀=20.7 nM) with anticancer activity. PRMT5-IN-48 can inhibit the growth of various cancer cells, induce apoptosis (apoptosis), and arrest the cell cycle at the G0/G1 phase. PRMT5-IN-48 can be used for non-Hodgkin lymphoma (NHL) research.

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CAS No.: 2640287-77-8
Formule: C₃₀H₃₇N₅O₃
Masse moléculaire:515.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PRMT5-IN-48 Chemical Structure

CAS No.: 2640287-77-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

PRMT5^[1]

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-468	IC₅₀	7.4 nM Compound: 24	Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human MDA-MB-468 assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]
NCI-H358	IC₅₀	5 nM Compound: 24	Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human NCI-H358 assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]
Z-138	IC₅₀	2.2 nM Compound: 24	Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay Antiproliferative activity against human Z138 cells assessed as cell growth inhibition measured after 7 days by CCK-8 assay	[PMID: 37366223]

Parmacokinetics

Species	Dose	Route	Note	T_1/2	Plasma Concentration	AUC	MRT	Clearance (CL)	V_d	T_max	Bioavailability
Rat	10 mg/kg	p.o.	SD Rats	0.4 h	1366.5 ng/mL	771 ng·h/mL	0.5 h	2.5 L/h/kg	1.4 L/kg	/	/
Rat	2 mg/kg	i.v.	SD Rats	2.2 h	894 ng/mL	1028.2 ng·h/mL	1.7 h	/	/	0.1 h	26.7 %

Chemical Information

CAS No. 2640287-77-8
Masse moléculaire 515.65
Formule C₃₀H₃₇N₅O₃
SMILES

O=C1C2=CC(NC3CC4(C3)CN(C4)C(C)=O)=NC=C2C5(CN1C[C@@H](CN6CCC(C=CC=C7)=C7C6)O)CC5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li QQ, et al. Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1(2H)-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin's Lymphoma. J Med Chem. 2025 Jan 9;68(1):108-134. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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PRMT5-IN-48

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PRMT5-IN-48 Related Classifications

HY-170792 Related Classifications