CD200R
CD200 receptor (CD200R, CD200R1, OX2R) is the inhibitory immunoreceptor for CD200, defining a specialized checkpoint that restrains myeloid cell activation. CD200R is a type I transmembrane protein of the Ig superfamily with two extracellular Ig domains structurally resembling CD200 itself, but distinguished by an extended cytoplasmic tail containing three NPXY motifs (unlike the two cytoplasmic tyrosines in CD200 which are absent), which upon CD200 engagement are phosphorylated by Src kinases and recruit Dok1/Dok2, SHIP and RasGAP, terminating Ras-MAPK and PI3K activation. CD200R is expressed on macrophages, dendritic cells, neutrophils, eosinophils, mast cells, basophils and subpopulations of T, B and NK cells. Its engagement suppresses respiratory burst, pro-inflammatory cytokine and chemokine production, and antigen presentation. CD200R signaling limits autoimmune neuroinflammation, graft rejection, allergy and virus-induced immunopathology, while tumor microenvironments and viruses downregulate or mimic the axis to evade macrophage surveillance; CD200R agonists are therapeutic candidates for inflammatory and autoimmune diseases.
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CD200R Protéines Recombinantes (13)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
