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(R)-Roscovitine

(Synonyms: Seliciclib; CYC202)
35 Cited Publications
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Based on 35 publication(s) in Google Scholar

(R)-Roscovitine (Seliciclib) is an orally bioavailable, selective and BBB-permeable CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.

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  • Pureté : 99.53%
  • CAS No.: 186692-46-6
  • Formule: C19H26N6O
  • Masse moléculaire:354.45
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • (R)-Roscovitine Chemical Structure
    (R)-Roscovitine Chemical Structure
  • Experimental Validation Results for (R)-Roscovitine
  • Experimental Validation Results for (R)-Roscovitine
  • Experimental Validation Results for (R)-Roscovitine
  • Experimental Validation Results for (R)-Roscovitine
  • Experimental Validation Results for (R)-Roscovitine
CAS No.: 186692-46-6
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  • (R)-Roscovitine Chemical Structure
    (R)-Roscovitine Chemical Structure
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    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Jun 29;97(6):e0037023. [Abstract]

    Customer Validation
     Cell cycle distribution of T24 and UMUC-3 cells was analyzed 48 h posttreatment with 10 mM nutlin-3a, 10 mM LEE011, 1 mM CI-1040, and 10 mM roscovitine. Then, 24 h posttreatment, cells were infected with 100 MOI dl70-3. After further 24-h cultivation, cells were fixed, PI stained, and FACS analyzed using a BD FACS Calibur Flow Cytometry System.

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    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Jun 29;97(6):e0037023. [Abstract]

    Customer Validation
     The levels of Rb and pRb expression were analyzed using immunoblotting in T24, UMUC-3, and A549 cells after 24-h treatment with the indicated concentrations of nutlin-3a, CI 1040, LEE011, and roscovitine.

  • 1/16

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Jun 29;97(6):e0037023. [Abstract]

    Customer Validation
     Roscovitine (10 μM; 48 h). Visualization and GFP expression analyses were performed in UMUC-3 cells 48 hours postinfection with E1-GFP/RGD with and without 10 mM LEE011.

  • 1/16

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: Mol Cancer Res. 2020 Jan;18(1):91-104. [Abstract]

    Customer Validation
     EW8 cells were released from a thymidine double block in the presence of LY2603618 (1 μM), Roscovitine (10 μM), or the combination of LY2603618 and Roscovitine. Cellular lysates were collected for immunoblotting 4 h after release from the block.

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    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: Neuroreport. 2018 Mar 7;29(4):241-246. [Abstract]

    Customer Validation
     R-E 235da1 exposure increases Cdk5 activity. Protein expression levels of P-histone H1 and Cdk5. P-histone H1 levels represent the activity of Cdk5. Bands for Cdk5 are the input. R-E 235da1 exposure increased Cdk5 activity.

  • (R)-Roscovitine