RET-IN-2
RET-IN-2 is a selective RET inhibitor with an IC50 of 61.2 nM. RET-IN-2 inhibits the phosphorylation of RET and its downstream STAT3 and AKT proteins in BaF3/CCDC6-RET cells. RET-IN-2 inhibits the proliferation of RET fusion-positive cells. RET-IN-2 can be used for cancer-related research.
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- CAS No.: 2095172-11-3
- Formule: C13H16N6O2
- Masse moléculaire:288.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
[1]|
STAT3 |
Akt |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
433 nM
Compound: 23c
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Antiproliferative activity against mouse BAF3 cells harboring CCDC6-RET fusion protein after 72 hrs by CCK8 assay
Antiproliferative activity against mouse BAF3 cells harboring CCDC6-RET fusion protein after 72 hrs by CCK8 assay
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[PMID: 28404375] |
In Vitro
RET-IN-2 inhibits BaF3/CCDC6-RET cell proliferation with an IC50 of 433 nM[1].
RET-IN-2 (0-1 μM) inhibits RET phosphorylation and downstream STAT3/AKT signaling in BaF3/CCDC6-RET cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2095172-11-3
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Masse moléculaire 288.31
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Formule C13H16N6O2
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SMILES
OC(C=1ON=C(C1)C2=NN(C3=NC=NC(N)=C23)C(C)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RET-IN-2 Related Classifications
HY-125014 Related Classifications
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