RS-23597
RS-23597 is a 5-HT4R antagonist with a Ki value of 19 nM against guinea pig 5-HT4R. RS-23597 inhibits the relaxation of the esophageal muscularis mucosae in rats. RS-23597 regulates 5-HT4R-Gs protein coupling and triggers the Gs-mediated cAMP signaling pathway. RS-23597 is applicable to the research of neurological diseases.
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- CAS No.: 172679-58-2
- Formule: C16H23ClN2O3
- Masse moléculaire:326.82
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Activité biologique
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5-HT4 Receptor 19 nM (Ki) |
RS-23597 (Compound 98) is a potent and selective 5-HT4 receptor antagonist in the rat esophageal muscularis mucosa, with a pA2 value of 7.8, and it exhibits only weak antagonistic activity against the 5-HT3 receptor[1].
RS-23597 binds to 5-HT4 receptors in guinea pig striatal membranes with an apparent Ki value of 19 nM, and functions as a partial agonist[2].
RS-23597 induces cAMP production in cells expressing human 5-HT4 receptors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 172679-58-2
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Masse moléculaire 326.82
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Formule C16H23ClN2O3
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SMILES
O=C(OCCCN1CCCCC1)C=2C=C(Cl)C(N)=CC2OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RS-23597 Related Classifications
HY-145457 Related Classifications
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