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Cat. No.: HY-109077

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Tigolaner

(Synonyms: BAY-1272858)

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Based on 1 Customer Validation

Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.37%
CAS No.: 1621436-41-6
Formule: C₂₁H₁₃ClF₈N₆O
Masse moléculaire:552.81

Stockage:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Tigolaner Chemical Structure

CAS No.: 1621436-41-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity^[1].

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In Vivo

Tigolaner (intravenous injection/topical administration; 1.5 mg/kg / 14.5 mg/kg; single dose) exerts anti-flea and anti-tick effects in cats^[1].
Plasma Pharmacokinetic Analysis in cats^[1]

Route	Dose rate mg/kg	T_1/2 (h)	T_max (h)	C_max (μg/L)	AUC_last (mg·h/L)	AUC_inf (mg·h/L)	CL_-pred (L/h/kg)	Vz_-pred (L/kg)
topical	14.5	568.2	297.0	1245.1	1516	1566	/	/
i.v.	1.5	515.4	/	/	298	300.1	0.005	4.00

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1621436-41-6
Appearance Solid
Masse moléculaire 552.81
Formule C₂₁H₁₃ClF₈N₆O
Color White to off-white
SMILES

FC(F)(C(C(C(F)(F)C(F)(F)F)=N1)=C(N2C=C(C(C=C3)=CC(C(NC4(CC4)C#N)=O)=C3Cl)C=N2)N1C)F
Synonyms

BAY-1272858
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvant et solubilité

In Vitro:

DMSO : 25 mg/mL (45.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8089 mL

9.0447 mL

18.0894 mL

5 mM

0.3618 mL

1.8089 mL

3.6179 mL

10 mM

0.1809 mL

0.9045 mL

1.8089 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mencke N, et al. Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats. Curr Res Parasitol Vector Borne Dis. 2023 Jun 22;4:100126. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8089 mL	9.0447 mL	18.0894 mL	45.2235 mL
	5 mM	0.3618 mL	1.8089 mL	3.6179 mL	9.0447 mL
	10 mM	0.1809 mL	0.9045 mL	1.8089 mL	4.5223 mL
	15 mM	0.1206 mL	0.6030 mL	1.2060 mL	3.0149 mL
	20 mM	0.0904 mL	0.4522 mL	0.9045 mL	2.2612 mL
	25 mM	0.0724 mL	0.3618 mL	0.7236 mL	1.8089 mL
	30 mM	0.0603 mL	0.3015 mL	0.6030 mL	1.5074 mL
	40 mM	0.0452 mL	0.2261 mL	0.4522 mL	1.1306 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

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Tigolaner

Covalent Screening Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Antiparasitic Compound library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

GABA Receptor Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Tigolaner

Covalent Screening Library

Neurotransmitter Receptor Compound Library

Anti-Alzheimer's Disease Compound Library

Antiparasitic Compound library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

GABA Receptor Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Tigolaner Related Classifications

HY-109077 Related Classifications