Traumatic Acid
Based on 3 publication(s) in Google Scholar
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis.
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- Pureté: 99.34%
- CAS No.: 6402-36-4
- Formule: C12H20O4
- Masse moléculaire:228.28
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Traumatic Acid
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Activité biologique
IC50: collagen biosynthesis[1]
Traumatic Acid (0.1, 1 μM; 5 days) significantly increases cell number in fibroblasts[1].
Traumatic Acid (0.1, 1 μM; 5 days) increases content of GPX activity and reduced glutathione, as well as decreases membrane phospholipid peroxidation in fibroblasts[1].
Traumatic Acid (0.1, 1 μM; 5 days) enhances the production and secretion of medium collagen in medium of fibroblasts[1].
Traumatic Acid (100, 200, 400, 600 μM; 48 h) significantly decreases live cell number, especially after 48h treatment at 100μM and 200μM in MCF-7 cells[2].
Traumatic Acid (50-600 μM; 24, 48 h) causes dose-and time-dependent reduction in cell viability and induces apoptosis in MCF-7 cells[2].
Traumatic Acid (50-200 μM; 24, 48 h) results in an oxidative damage of protein in MCF-7 cells[2].
Traumatic Acid (100, 200 μM; 24, 48 h) efficiently enhances oxidative stress level in MCF-7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Fibroblasts
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Concentration:0.1, 1 µM
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Incubation Time:5 days
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Result:Caused a significant increase in cell number, especially on day 1 at a concentration of 1 µM.
Increased cell number of 133 % and 118 % compared to the untreated control cells for concentrations of 1 and 0.1 µM, respectively.
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Cell Line:Fibroblasts
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Concentration:0.1, 1 µM
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Incubation Time:5 days
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Result:Increased total protein content of 183 % and 90% compared to the control at concentrations of 1 and 0.1 µM on day 1.
Increased collagen content of 72 % at 0.1 µM (on the day 3) and of 51 % at 1 µM (on the day 1) compared to the control.
Increased GPX activity by 111 % and 97 % at concentrations of 1 and 0.1 µM compared to the control.
Increased content of reduced glutathione of 86 % and 80% at 0.1 and 1 µM, respectively.
Decreased membrane phospholipid peroxidation.
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Cell Line:MCF-7 cells
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Concentration:100, 200, 400, 600 µM
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Incubation Time:48 h
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Result:Decreasd live cell number of about 76% at 100 µM concentration.
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Cell Line:MCF-7 cells
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Concentration:50-200 µM
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Incubation Time:24, 48 h
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Result:Increased thiol group content of 167% at 100µM and 24 h.
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Cell Line:MCF-7 cells
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Concentration:100, 200 µM
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Incubation Time:24, 48 h
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Result:Increased the amount of ROS.
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Cell Line:MCF-7 cells
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Concentration:50-600 µM
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Incubation Time:24, 48 h
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Result:Increased level of apoptosis in a time- and dose-dependent manner.
Chemical Information
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CAS No. 6402-36-4
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Appearance Solid
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Masse moléculaire 228.28
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Formule C12H20O4
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Color White to off-white
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SMILES
O=C(O)/C=C/CCCCCCCCC(O)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Redox Biol
LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX. [Abstract]2024 Oct:76:103346. PMID: 39260063 -
Toxicol Sci
Identification of a substrate of the renal tubular transporters for detecting drug-induced early acute kidney injury. [Abstract]2024 Oct 1;201(2):190-205. PMID: 39041788 -
Solvant et solubilité
DMSO : 250 mg/mL (1095.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Jabłońska-Trypuć A, et al. Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts.Lipids. 2016 Sep;51(9):1021-35. [Content Brief]
[2]. Jabłońska-Trypuć A, et al. Traumatic acid toxicity mechanisms in human breast cancer MCF-7 cells. Regul Toxicol Pharmacol. 2019 Aug;106:137-146. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3806 mL | 21.9029 mL | 43.8059 mL | 109.5146 mL |
| 5 mM | 0.8761 mL | 4.3806 mL | 8.7612 mL | 21.9029 mL | |
| 10 mM | 0.4381 mL | 2.1903 mL | 4.3806 mL | 10.9515 mL | |
| 15 mM | 0.2920 mL | 1.4602 mL | 2.9204 mL | 7.3010 mL | |
| 20 mM | 0.2190 mL | 1.0951 mL | 2.1903 mL | 5.4757 mL | |
| 25 mM | 0.1752 mL | 0.8761 mL | 1.7522 mL | 4.3806 mL | |
| 30 mM | 0.1460 mL | 0.7301 mL | 1.4602 mL | 3.6505 mL | |
| 40 mM | 0.1095 mL | 0.5476 mL | 1.0951 mL | 2.7379 mL | |
| 50 mM | 0.0876 mL | 0.4381 mL | 0.8761 mL | 2.1903 mL | |
| 60 mM | 0.0730 mL | 0.3650 mL | 0.7301 mL | 1.8252 mL | |
| 80 mM | 0.0548 mL | 0.2738 mL | 0.5476 mL | 1.3689 mL | |
| 100 mM | 0.0438 mL | 0.2190 mL | 0.4381 mL | 1.0951 mL |
Traumatic Acid Related Classifications
HY-119358 Related Classifications
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