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Cat. No.: HY-N29777

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Cabraleahydroxylactone

Cabraleahydroxylactone is a dammarane triterpenoid with antimycobacterial activity against Mycobacterium tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 35833-69-3
Formula: C₂₇H₄₄O₃
Molecular Weight:416.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Cabraleahydroxylactone Chemical Structure

CAS No.: 35833-69-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cabraleahydroxylactone is a dammarane triterpenoid with antimycobacterial activity against Mycobacterium tuberculosis^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: 17	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24547740]
COLO 205	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay	[PMID: 17346076]
HepG2	IC₅₀	>50 μM Compound: 17	Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24547740]
HT-29	ED₅₀	>10 μM Compound: cabraleahydroxylactone	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 23301897]
K562	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 17346076]
K562/Adr	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human doxorubicin-resistant K562/Adr cells after 48 hrs by MTT assay Cytotoxicity against human doxorubicin-resistant K562/Adr cells after 48 hrs by MTT assay	[PMID: 17346076]
K562/Adr	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human doxorubicin-resistant K562/Adr cells in presence of 1 uM doxorubicin after 48 hrs by MTT assay Cytotoxicity against human doxorubicin-resistant K562/Adr cells in presence of 1 uM doxorubicin after 48 hrs by MTT assay	[PMID: 17346076]
KB	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human KB cells after 48 hrs by MTT assay Cytotoxicity against human KB cells after 48 hrs by MTT assay	[PMID: 17346076]
MCF7	IC₅₀	>100 μM Compound: 15	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 17346076]
MCF7	IC₅₀	>50 μM Compound: 17	Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 24547740]
RAW264.7	IC₅₀	>100 μM Compound: 17	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay	[PMID: 24547740]

Chemical Information

CAS No. 35833-69-3
Molecular Weight 416.64
Formula C₂₇H₄₄O₃
SMILES

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]3([H])[C@]4(OC(CC4)=O)C)C)([H])[C@@]5([C@@](C(C)([C@@H](CC5)O)C)([H])CC1)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jarinporn Phongmaykin, et al. A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus. Arch Pharm Res. 2008 Jan;31(1):21-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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