CDK-IN-20
CDK-IN-20 is a selective CDK2 inhibitor with an IC50 value of <10 nM. CDK-IN-20 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2776187-63-2
- Formula: C16H17F3N4O5S
- Molecular Weight:434.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
CDK-IN-20 (Compound E7) exhibits moderate inhibitory activity against CDK1, CDK4, and CDK6, with IC50 values ranging from 100 nM to 1 μM; it shows extremely weak inhibitory activity against CDK7 and CDK9, with IC50 > 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2776187-63-2
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Molecular Weight 434.39
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Formula C16H17F3N4O5S
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SMILES
FC(F)(F)C(C(O[C@H]1[C@H](COCC1)O)=N2)=CN=C2NC3=CC=C(C=C3)S(N)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK-IN-20 Related Classifications
HY-184320 Related Classifications
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