E-55888
E-55888 is a selective and potent agonist of 5-HT7 receptor and 5-HT1A receptor with Ki values of 2.5 nM and 700 nM, respectively, which has analgesic and antinociceptive effects. E-55888 reduces the nociceptive response of Capsaicin (HY-10448) sensitized mice.
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- CAS. Nr.: 1034142-33-0
- Formel: C16H23N3
- Molecular Weight:257.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
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5-HT1A Receptor |
5-HT7 Receptor |
Chemical Information
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CAS. Nr. 1034142-33-0
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Molecular Weight 257.37
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Formel C16H23N3
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SMILES
CC1=C(C2=CC(CCN(C)C)=CC=C2)C(C)=NN1C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-247. [Content Brief]
[2]. Hansen HD, et al. Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888. Bioorg Med Chem Lett. 2015 May 1;25(9):1901-4. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
E-55888 Related Classifications
HY-113866 Related Classifications
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