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Art. -Nr.: HY-P9934

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Biologically Validated

Abciximab

Name: Abciximab
Brand: MedChemExpress
SKU: HY-P9934
Price: 260.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: C7E3)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.71%
CAS. Nr.: 143653-53-6
Molecular Weight:47.62 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Abciximab Chemical Structure

CAS. Nr.: 143653-53-6

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Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Publications (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Fab-G1-kappa

Species Reactivity

Human

IC₅₀ & Target

ITGA2B_ITGB3

Alle Integrin Isoform-spezifische Produkte anzeigen :

In Vitro

Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet α_IIbβ₃ integrin^[2].
Abciximab appears to have similar affinity for the α_IIbβ₃ and α_vβ₃ integrins and redistributes between them^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats weighing 200-250 g, balloon angioplasty model^[2]
Dosage:

0.25 mg/kg/day
Administration:

Intravenous injection, 28 days
Result:

Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB₂ concentration.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

3674 [NCBI] & 3690 [NCBI]

Accession

P08514 & P05106

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Fab-G1-kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Abciximab on Fab2G biosensor, can bind Integrin alpha 2B beta 3 Protein, Human (HEK293, His, HY-P77716) with an affinity constant of 2.475E-09 M as determined in BLI assay.

Chemical Information

CAS. Nr. 143653-53-6
Appearance Liquid
Molecular Weight 47.62 kDa
Color Colorless to light yellow
SMILES

[Abciximab]
Synonyms

C7E3
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

All Cell Imaging/Staining

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Journal Impact Factor

Am J Respir Cell Mol Biol

GP IIb/IIIa-ICAM-1 Mediated Platelet-Endothelial Adhesion Exacerbates Pulmonary Hypertension. [Abstract]

2025 Feb 28. PMID: 40019848

Abciximab purchased from MedChemExpress. Usage Cited in: Am J Respir Cell Mol Biol. 2025 Feb 28. [Abstract]

Abciximab (0.05 μM) significantly reduced platelet–endothelial cell adhesion.
Blood Vessel Thromb Hemost

Endo-chip laser-induced thrombus formation: a vessel-on-chip model for in vitro testing of antithrombotic agents. [Abstract]

2025 Jul 18;2(4):100096. PMID: 41030610

Abciximab purchased from MedChemExpress. Usage Cited in: Blood Vessel Thromb Hemost. 2025 Jul 18;2(4):100096. [Abstract]

Abciximab (20 μg/mL; 60 min) resulted in significant inhibition of platelet thrombus formation.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Ibbotson T, et al. Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation. Drugs. 2003;63(11):1121-63. [Content Brief]

[2]. Wu CH, et al. Mechanisms involved in the inhibition of neointimal hyperplasia by abciximab in a rat model of balloon angioplasty. Thromb Res. 2001 Feb 1;101(3):127-38. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Abciximab

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Publications (2)
Reinheit & Dokumentation
Verweise

1/16

Fab-G1-kappa
1/16

Loaded Abciximab on Fab2G biosensor, can bind Integrin alpha 2B beta 3 Protein, Human (HEK293, His, HY-P77716) with an affinity constant of 2.475E-09 M as determined in BLI assay.
1/16

Abciximab purchased from MedChemExpress. Usage Cited in: Am J Respir Cell Mol Biol. 2025 Feb 28. [Abstract]

Customer Validation
Abciximab (0.05 μM) significantly reduced platelet–endothelial cell adhesion.
1/16

Abciximab purchased from MedChemExpress. Usage Cited in: Blood Vessel Thromb Hemost. 2025 Jul 18;2(4):100096. [Abstract]

Customer Validation
Abciximab (20 μg/mL; 60 min) resulted in significant inhibition of platelet thrombus formation.
1/16

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Abciximab

Publications Citing Use of MedChemExpress (MCE) Abciximab

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