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Art. -Nr.: HY-117118A

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AC-90179

AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound.

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CAS. Nr.: 359878-19-6
Formel: C₂₃H₃₁ClN₂O₂
Molecular Weight:402.96

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AC-90179 Chemical Structure

CAS. Nr.: 359878-19-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AC-90179 is a selective 5-HT2A receptor inverse agonist (K_i = 2.1 nM) and 5-HT2C antagonist, a potential antipsychotic compound^[1].

IC₅₀ & Target

5-HT_2A Receptor

5-HT_2C Receptor

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

AC-90179 (1-10 mg/kg i.p., 30 min) completely reversed the DOI (0.3-3 mg/kg i.p., 15 min)-induced suppression of response rates, whereas at lower doses of AC-90179 (1 mg/kg i.p., 30 min), only partial reversal of DOI-induced inhibition was observed in C57BL/6 mice^[1].
AC-90179(1 or 3 mg/kg s.c.) can attenuate phencyclidine (3 mg/kg i.p., 15 min)-induced hyperactivity of NSA mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 359878-19-6
Molecular Weight 402.96
Formel C₂₃H₃₁ClN₂O₂
SMILES

O=C(N(CC1=CC=C(C)C=C1)C2CCN(C)CC2)CC3=CC=C(OC)C=C3.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kimberly E. Vanover, et al. Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 943-951

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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AC-90179

High-Throughput Bioactive Compound Library

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AC-90179 Related Classifications

HY-117118A Related Classifications