Adatanserin
Adatanserin (WY-50324) is a high affinity, selective and partial agonist for the 5-HT1A receptor with a Ki of 1 nM. Adatanserin is a moderate affinity 5-HT2 receptor antagonist with a Ki of 73 nM. Adatanserin shows significant anxiolytic and antidepressant activity in an animal conflict model.
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- CAS. Nr.: 127266-56-2
- Formel: C21H31N5O
- Molecular Weight:369.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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5-HT1A Receptor |
5-HT1A Receptor 1 nM (Ki) |
5-HT2 Receptor 73 nM (Ki) |
Chemical Information
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CAS. Nr. 127266-56-2
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Molecular Weight 369.50
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Formel C21H31N5O
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SMILES
O=C(NCCN1CCN(CC1)C2=NC=CC=N2)C34CC(CC(C4)C5)CC5C3
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Synonyms
WY-50324; SEB-324
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. M A Abou-Gharbia, et al. Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. [Content Brief]
[2]. A Singh, et al. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Adatanserin Related Classifications
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