Alafosfalin
Based on 1 Customer Validation
Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties.
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- Reinheit: 99.70%
- CAS. Nr.: 60668-24-8
- Formel: C5H13N2O4P
- Molecular Weight:196.14
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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β-lactam |
Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pairs of male SpragueDawley rats (250 to 350 g)[2]
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Dosage:20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis)
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Administration:Administrated by s.c.
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Result:Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes.
Chemical Information
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CAS. Nr. 60668-24-8
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Appearance Solid
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Molecular Weight 196.14
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Formel C5H13N2O4P
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Color White to off-white
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SMILES
OP(O)([C@@H](NC([C@@H](N)C)=O)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
H2O : 250 mg/mL (1274.60 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. H B Maruyama, et al. Alafosfalin, a New Inhibitor of Cell Wall Biosynthesis: In Vitro Activity Against Urinary Isolates in Japan and Potentiation With Beta-Lactams. Antimicrob Agents Chemother. 1979 Oct;16(4):444-51. [Content Brief]
[2]. J G Allen, et al. Phosphonopeptides as Antibacterial Agents: Metabolism and Pharmacokinetics of Alafosfalin in Animals and Humans. Antimicrob Agents Chemother. 1979 Sep;16(3):306-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0984 mL | 25.4920 mL | 50.9840 mL | 127.4600 mL |
| 5 mM | 1.0197 mL | 5.0984 mL | 10.1968 mL | 25.4920 mL | |
| 10 mM | 0.5098 mL | 2.5492 mL | 5.0984 mL | 12.7460 mL | |
| 15 mM | 0.3399 mL | 1.6995 mL | 3.3989 mL | 8.4973 mL | |
| 20 mM | 0.2549 mL | 1.2746 mL | 2.5492 mL | 6.3730 mL | |
| 25 mM | 0.2039 mL | 1.0197 mL | 2.0394 mL | 5.0984 mL | |
| 30 mM | 0.1699 mL | 0.8497 mL | 1.6995 mL | 4.2487 mL | |
| 40 mM | 0.1275 mL | 0.6373 mL | 1.2746 mL | 3.1865 mL | |
| 50 mM | 0.1020 mL | 0.5098 mL | 1.0197 mL | 2.5492 mL | |
| 60 mM | 0.0850 mL | 0.4249 mL | 0.8497 mL | 2.1243 mL | |
| 80 mM | 0.0637 mL | 0.3186 mL | 0.6373 mL | 1.5932 mL | |
| 100 mM | 0.0510 mL | 0.2549 mL | 0.5098 mL | 1.2746 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Alafosfalin Related Classifications
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