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Art. -Nr.: HY-183304

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Anticancer agent 318

Anticancer agent 318 (Compound 8 (6)) is a selective anticancer agent. Anticancer agent 318 can be metabolized by CYP1A1, CYP1A2 and CYP1B1. After bioactivation, Anticancer agent 318 exerts antiproliferative activity in breast cancer cells expressing CYP1. Anticancer agent 318 can be used in the research of breast cancer.

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CAS. Nr.: 2482789-24-0
Formel: C₂₀H₁₇NO₄
Molecular Weight:335.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 318 Chemical Structure

CAS. Nr.: 2482789-24-0

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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Beschreibung

IC₅₀ & Target^[1]

CYP1A1

CYP1A2

CYP1B1

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In Vitro

The anticancer agent 318 potently inhibits the proliferation of CYP1-expressing breast cancer cell lines MDA-MB-468 (IC₅₀ = 0.08 μM) and TCDD-induced MCF-7 (IC₅₀ = 0.006 μM), shows no toxicity toward non-tumorigenic MCF-10A cells (IC₅₀ = 100 μM), and its activity depends on CYP1-mediated bioactivation^[1].
The anticancer agent 318 (0-30 min) is metabolized by CYP1A1, CYP1A2 and CYP1B1 (but not CYP3A4) enzymes, producing four distinct metabolites via demethylenation, O-demethylation and hydroxylation reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2482789-24-0
Molecular Weight 335.35
Formel C₂₀H₁₇NO₄
SMILES

COC1=CC(OC)=C(C=C1)C2=CC(C3=CC4=C(OCO4)C=C3)=CC=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ruparelia K, et al. CYP1-bioactivated 2,4-diaryl-substituted pyridine analogues with remarkable activity in a breast cancer in vitro model. Bioorg Med Chem Lett. 2026;137:130648. [Content Brief]

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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Anticancer agent 318

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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Calculators

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Anticancer agent 318 Related Classifications

HY-183304 Related Classifications