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Art. -Nr.: HY-183698

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CDK9-IN-51

CDK9-IN-51 is a CDK9 inhibitor. CDK9-IN-51 binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103. CDK9-IN-51 exhibits antiproliferative activity against multiple cancer cells. CDK9-IN-51 can be used for the research of cancer, such as lung carcinoma, cervical carcinoma and breast carcinoma.

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CAS. Nr.: 2853500-43-1
Formel: C₂₁H₁₆FN₃O
Molecular Weight:345.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK9-IN-51 Chemical Structure

CAS. Nr.: 2853500-43-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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^[1]

CDK9

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In Vitro

CDK9-IN-51 (Compound D3) binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103, with a binding free energy of -85.33 kcal/mol and a docking score of -9.186 kcal/mol^[1].
CDK9-IN-51 potently inhibits the proliferation of multiple cancer cell lines, including A549, SiHa, and MCF-7, with
IC₅₀ values of 6.09, 3.33, and 9.74 μM,
respectively, and exhibits minimal toxicity to normal HEK-293t cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2853500-43-1
Molecular Weight 345.37
Formel C₂₁H₁₆FN₃O
SMILES

FC(C=C(C1=CC=NC=C1)C=C2)=C2NC(CC3=CNC4=CC=CC=C43)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Reddyrajula R, et al. Development of potential CDK9 inhibitors through pharmacophore-based virtual screening, 3D-QSAR, molecular docking, MD simulation, and in vitro anticancer evaluation. Sci Rep. Published online April 28, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CDK9-IN-51

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

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CDK9-IN-51 Related Classifications

HY-183698 Related Classifications

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