Art. -Nr.: HY-17628

Cefiderocol

(Synonyms: S-649266)

20 Cited Publications

Kundenbewertung

Based on 20 publication(s) in Google Scholar

Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC₅₀s of 2 μg/mL or less.

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Reinheit: 99.60%
CAS. Nr.: 1225208-94-5
Formel: C₃₀H₃₄ClN₇O₁₀S₂
Molecular Weight:752.21

Speicherung:

-20°C, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

Cefiderocol Chemical Structure

CAS. Nr.: 1225208-94-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Publications (20)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC₅₀s of 2 μg/mL or less.

IC₅₀ & Target

β-lactam

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Cefiderocol (S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Cefiderocol has affinity mainly for PBP3 of Enterobacteriaceae and nonfermenting bacteria similar to that of GR20263. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa show no significant impact on the activity of cefiderocol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1225208-94-5
Appearance Solid
Molecular Weight 752.21
Formel C₃₀H₃₄ClN₇O₁₀S₂
Color White to off-white
SMILES

O=C(C(N12)=C(C[N+]3(CCNC(C4=CC=C(O)C(O)=C4Cl)=O)CCCC3)CS[C@]2([H])[C@H](NC(/C(C5=CSC(N)=N5)=N\OC(C)(C(O)=O)C)=O)C1=O)[O-]
Synonyms

S-649266
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (20)

All Microbiological Assay

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Journal Impact Factor

Drug Resist Updat

Intracellular Zn²⁺ dynamics regulate cefiderocol resistance in Klebsiella pneumoniae. [Abstract]

2026 May:86:101377. PMID: 41702031
Clin Microbiol Infect

Performance of discs, sensititre EUMDROXF microplates and MTS gradient strips for the determination of the susceptibility of multidrug resistant Pseudomonas aeruginosa to cefiderocol. [Abstract]

2023 May;29(5):652.e1-652.e8. PMID: 36587736
Bioorg Chem

Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates. [Abstract]

2020 Jan;95:103550. PMID: 31911309
RSC Adv

Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation. [Abstract]

2024 Jan 18;14(5):2905-2917. PMID: 38239435
Antibiotics (Basel)

Comparison of Disk Diffusion, E-Test, and Broth Microdilution Methods for Testing In Vitro Activity of Cefiderocol in Acinetobacter baumannii. [Abstract]

2023 Jul 20;12(7):1212. PMID: 37508308

Cefiderocol purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2023 Jul 20;12(7):1212. [Abstract]

Distribution of Cefiderocol MICs determined with the standard BMD method according to the acquired carbapenem-resistance marker(s).
Antimicrob Agents Chemother

A genomics-informed mechanism-based pharmacokinetic/pharmacodynamic model of cefiderocol and ceftazidime/avibactam against carbapenem-resistant Achromobacter xylosoxidans. [Abstract]

2026 Mar 4;70(3):e0126325. PMID: 41586494

Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Mar 4;70(3):e0126325. [Abstract]

Expected in vitro PD effect with different infusion durations in the Ax114 strain and Ax130 strain. Simulations were performed using body weight-based dosing of Ceftazidime/Avibactam (50/12.5 mg/kg, capped at 2,000/500 mg) and Cefiderocol (60 mg/kg, capped at 2,000 mg) administered every 8 h. Solid lines represent the median predicted bacterial response, and shaded areas indicate the 95% confidence interval based on the MBM simulations.

Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2026 Mar 4;70(3):e0126325. [Abstract]

CFU reduction (log₁₀ CFU/mL) with Ceftazidime/Avibactam and Cefiderocol as monotherapies (blue) and in combination (red), compared to the growth control (green). Data are shown for Ax114 (small circles) and Ax130 (larger circles with grid), highlighting differential responses across strains and treatments.
Antimicrob Agents Chemother

Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales. [Abstract]

2025 Dec 5:e0084225. PMID: 41347523

Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 Dec 5:e0084225. [Abstract]

Activity of Aztreonam-avibactam, Cefiderocol, Cefepime-taniborbactam, Tigecycline, and Colistin against MBL-producing Enterobacterales stratified by country, organism, and MBL type.
Antimicrob Agents Chemother

Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii. [Abstract]

2024 Mar 6;68(3):e0112023. PMID: 38289044
Antimicrob Agents Chemother

Structural role of K224 in taniborbactam inhibition of NDM-1. [Abstract]

2024 Feb 7;68(2):e0133223. PMID: 38174924

Cefiderocol purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. [Abstract]

Minimum inhibitory concentrations (MICs) of different β-lactams against E. coli DH10B strains harboring the pHSG298 bla_NDM-1(K224X) gene. The heat map represents the doubling dilution changes in the MIC values of the K224X variants compared with that of the NDM-1 wild type. The results shown are the mode of three biological replicates. FEP, cefepime; CAZ, ceftazidime; IMI, imipenem; TBPM, tebipenem; FDC, Cefiderocol; WT, wild type.
Front Microbiol

Proteomic and Transcriptomic Analyses Indicate Reduced Biofilm-Forming Abilities in Cefiderocol-Resistant Klebsiella pneumoniae. [Abstract]

2022 Jan 3:12:778190. PMID: 35046911
J Infect Public Health

High efficacy and enhanced synergistic activity of the novel siderophore-cephalosporin cefiderocol against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae from inpatients attending a single hospital in the United Arab Emirates. [Abstract]

2023 Dec:16 Suppl 1:33-44. PMID: 37953111
Sci Rep

Sporadic cefiderocol resistance in Escherichia coli from the United Arab Emirates involves multifactorial mechanisms reversible by novel beta-lactamase inhibitors. [Abstract]

2025 Sep 29;15(1):33616. PMID: 41023121
Sci Rep

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University. [Abstract]

2024 Feb 1;14(1):2657. PMID: 38302552
Open Forum Infect Dis

Aztreonam-avibactam Demonstrates Potent Activity Against Carbapenem-resistant Enterobacterales Collected From US Medical Centers Over a 6-year Period (2017-2022). [Abstract]

2025 Apr 25;12(5):ofaf250. PMID: 40365080
Microbiol Spectr

Proteomic Investigation of the Antibacterial Mechanism of Cefiderocol against Escherichia coli. [Abstract]

2022 Oct 26;10(5):e0109322. PMID: 35980225
J Antimicrob Chemother

Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]

2026 Feb 2;81(3):dkag034. PMID: 41648989
PLoS One

In vitro activity of ceftazidime/avibactam, cefiderocol, meropenem/vaborbactam and imipenem/relebactam against clinical strains of the Stenotrophomonas maltophilia complex. [Abstract]

2024 Apr 18;19(4):e0298577. PMID: 38635685
Microb Drug Resist

Overcoming Multi-Drug-Resistant Klebsiella pneumoniae Infections. [Abstract]

2025 Sep 8. PMID: 40916806
Res Sq

2026 Mar 9.
Preprints

2023 Jun 21.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (132.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1.06 mg/mL (1.41 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3294 mL

6.6471 mL

13.2942 mL

5 mM

0.2659 mL

1.3294 mL

2.6588 mL

10 mM

0.1329 mL

0.6647 mL

1.3294 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (2.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

Cell Assay^[1]

For the determination of cefiderocol MIC, iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) is prepared, except for the cases that are required to determine MICs under specific conditions. The quality control MIC ranges of cefiderocol are 0.06 to 0.5 μg/mL for both E. coli ATCC 25922 and P. aeruginosa ATCC 27853. For anaerobic bacteria, brucella agar supplemented with hemin, vitamin K1, and laked sheep blood is used^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (295 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ito A, et al. In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria. Antimicrob Agents Chemother. 2017 Dec 21;62(1). [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.3294 mL	6.6471 mL	13.2942 mL	33.2354 mL
DMSO	5 mM	0.2659 mL	1.3294 mL	2.6588 mL	6.6471 mL
	10 mM	0.1329 mL	0.6647 mL	1.3294 mL	3.3235 mL
	15 mM	0.0886 mL	0.4431 mL	0.8863 mL	2.2157 mL
	20 mM	0.0665 mL	0.3324 mL	0.6647 mL	1.6618 mL
	25 mM	0.0532 mL	0.2659 mL	0.5318 mL	1.3294 mL
	30 mM	0.0443 mL	0.2216 mL	0.4431 mL	1.1078 mL
	40 mM	0.0332 mL	0.1662 mL	0.3324 mL	0.8309 mL
	50 mM	0.0266 mL	0.1329 mL	0.2659 mL	0.6647 mL
	60 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5539 mL
	80 mM	0.0166 mL	0.0831 mL	0.1662 mL	0.4154 mL
	100 mM	0.0133 mL	0.0665 mL	0.1329 mL	0.3324 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cefiderocol

20 Cited Publications

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Cefiderocol

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

Publications Citing Use of MedChemExpress (MCE) Cefiderocol

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (20)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cefiderocol

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

Publications Citing Use of MedChemExpress (MCE) Cefiderocol

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (20)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cefiderocol Related Classifications

HY-17628 Related Classifications