Art. -Nr.: HY-B1625

Deferoxamine

(Synonyms: Deferoxamine B; Deferriferrioxamine B; Deferrioxamine)

438 Cited Publications

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Based on 438 publication(s) in Google Scholar

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19.

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Reinheit: 99.57%
CAS. Nr.: 70-51-9
Formel: C₂₅H₄₈N₆O₈
Molecular Weight:560.68

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Deferoxamine Chemical Structure

CAS. Nr.: 70-51-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (438)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3.5 μM Compound: DFO	Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay	[PMID: 36105345]
A549	IC₅₀	7.5 μM Compound: DFO	Antiproliferative activity at human A549 cells after 72 hrs by MTT assay Antiproliferative activity at human A549 cells after 72 hrs by MTT assay	[PMID: 22861499]
AML12	EC₅₀	8.83 μM Compound: DFO	Protection against CCl4-induced ferroptosis in mouse AML12 cells assessed as cell viability Protection against CCl4-induced ferroptosis in mouse AML12 cells assessed as cell viability	[PMID: 39047113]
DLD-1	IC₅₀	2.9 μM Compound: 100	Antiproliferative activity against human DLD-1 cells assessed as reduction in cell proliferation Antiproliferative activity against human DLD-1 cells assessed as reduction in cell proliferation	[PMID: 33445154]
DMS-53	IC₅₀	10 μM Compound: DFO	Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay	[PMID: 22861499]
HCT-116	IC₅₀	>200 μM Compound: I, DFO	Dark cytotoxicity against human HCT116 cells expressing wild type p53 after 96 hrs by MTT assay Dark cytotoxicity against human HCT116 cells expressing wild type p53 after 96 hrs by MTT assay	[PMID: 24900837]
HCT-116	IC₅₀	>200 μM Compound: I, DFO	Dark cytotoxicity against p53-deficient human HCT116 cells after 96 hrs by MTT assay Dark cytotoxicity against p53-deficient human HCT116 cells after 96 hrs by MTT assay	[PMID: 24900837]
HeLa	IC₅₀	>50 μM Compound: DFO, desferoxamine	Cytotoxicity against human HeLa cells after 72 hrs by MTS assay Cytotoxicity against human HeLa cells after 72 hrs by MTS assay	[PMID: 18345610]
HepaRG	IC₅₀	50 μM Compound: DFO	Antiproliferative activity against human HepaRG cells after 72 hrs by MTT assay Antiproliferative activity against human HepaRG cells after 72 hrs by MTT assay	[PMID: 20036563]
HepaRG	IC₅₀	70 μM Compound: DFO	Antiproliferative activity against human HepaRG cells after 72 hrs by MTT assay in presence of iron(3) Antiproliferative activity against human HepaRG cells after 72 hrs by MTT assay in presence of iron(3)	[PMID: 20036563]
HepG2	IC₅₀	>100 μM Compound: DFO	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 29233652]
HL-60	GI₅₀	18.4 μM Compound: DFO	Cytotoxicity against human HL60 cells by alamar blue assay Cytotoxicity against human HL60 cells by alamar blue assay	[PMID: 23266185]
HT-29	IC₅₀	36.1 μM Compound: DFO, desferoxamine	Cytotoxicity against human HT29 cells after 72 hrs by MTS assay Cytotoxicity against human HT29 cells after 72 hrs by MTS assay	[PMID: 18345610]
K562	GI₅₀	33.1 μM Compound: DFO	Cytotoxicity against human K562 cells Cytotoxicity against human K562 cells	[PMID: 23266185]
MDA-MB-231	IC₅₀	6.1 μM Compound: DFO	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 36105345]
MDCK	IC₅₀	9.49 μM Compound: 1, DFOB	Toxicity in MDCK cells by MTT method Toxicity in MDCK cells by MTT method	[PMID: 20041672]
MRC5	IC₅₀	>10 μM Compound: DFO	Antiproliferative activity at human MRC5 cells after 72 hrs by MTT assay Antiproliferative activity at human MRC5 cells after 72 hrs by MTT assay	[PMID: 22861499]
MRC5	IC₅₀	9 μM Compound: DFO	Antiproliferative activity against human MRC5 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MRC5 cells incubated for 72 hrs by MTT assay	[PMID: 36105345]
NIH3T3	IC₅₀	4.9 μM Compound: DFO	Inhibition of erastin-induced ferroptosis in mouse NIH/3T3 cells after 24 hrs by WST-8 assay Inhibition of erastin-induced ferroptosis in mouse NIH/3T3 cells after 24 hrs by WST-8 assay	[PMID: 31531196]
NIH3T3	IC₅₀	9 μM Compound: DFO	Inhibition of TBHP-induced ferroptosis in mouse NIH/3T3 cells after 12 hrs by WST-8 assay Inhibition of TBHP-induced ferroptosis in mouse NIH/3T3 cells after 12 hrs by WST-8 assay	[PMID: 31531196]
SK-N-MC	IC₅₀	10 μM Compound: DFO	Antiproliferative activity at human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity at human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 22861499]
SK-N-MC	IC₅₀	12.5 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 22858101]
SK-N-MC	IC₅₀	14.22 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells by MTT assay Antiproliferative activity against human SK-N-MC cells by MTT assay	[PMID: 17963372]
SK-N-MC	IC₅₀	16.04 μM Compound: 1, DFOB	Toxicity in human SK-N-MC cells by MTT method Toxicity in human SK-N-MC cells by MTT method	[PMID: 20041672]
SK-N-MC	IC₅₀	16.81 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 28841514]
SK-N-MC	IC₅₀	17.07 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 21055950]
SK-N-MC	IC₅₀	17.07 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 22172311]
SK-N-MC	IC₅₀	21.63 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells measured after 72 hrs at 37 degC by MTT assay Antiproliferative activity against human SK-N-MC cells measured after 72 hrs at 37 degC by MTT assay	[PMID: 23312948]
SK-N-MC	IC₅₀	22 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells Antiproliferative activity against human SK-N-MC cells	[PMID: 19601577]
SK-N-MC	IC₅₀	22.7 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTS assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTS assay	[PMID: 21846118]
SK-N-MC	IC₅₀	22.7 μM Compound: DFO	Cytotoxicity against human SK-N-MC cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SK-N-MC cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23276209]
SK-N-MC	IC₅₀	4.51 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 17602603]
SK-N-MC	IC₅₀	5 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 19601577]
SK-N-MC	IC₅₀	7.35 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 19216562]
SK-N-MC	IC₅₀	8.58 μM Compound: DFO	Antiproliferative activity against human SK-N-MC cells after 96 hrs by MTT assay Antiproliferative activity against human SK-N-MC cells after 96 hrs by MTT assay	[PMID: 17064069]
SK-N-MC	IC₅₀	9.89 μM Compound: DFO	Cytotoxicity against human SK-N-MC cells after 72 hrs by MTT assay Cytotoxicity against human SK-N-MC cells after 72 hrs by MTT assay	[PMID: 20303768]
SW480	IC₅₀	3.8 μM Compound: 100	Antiproliferative activity against human SW480 cells assessed as reduction in cell proliferation Antiproliferative activity against human SW480 cells assessed as reduction in cell proliferation	[PMID: 33445154]
U2OS	EC₅₀	17.8 μM Compound: DFO	Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubation by luciferase reporter gene assay Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubation by luciferase reporter gene assay	[PMID: 22172704]
U373-MAGI	CC₅₀	>400 μM Compound: Deferoxamine	Cytotoxicity against human U373-MAGI cells by CellTitre-Glo assay Cytotoxicity against human U373-MAGI cells by CellTitre-Glo assay	[PMID: 24120088]
U373-MAGI	EC₅₀	384 μM Compound: Deferoxamine	Antiviral activity against HIV1 infected in human U373-MAGI cells incubated for 2 hrs prior to viral infection followed by compound washout after 24 hrs measured 72 hrs post-infection by flow cytometry Antiviral activity against HIV1 infected in human U373-MAGI cells incubated for 2 hrs prior to viral infection followed by compound washout after 24 hrs measured 72 hrs post-infection by flow cytometry	[PMID: 24120088]

In Vitro

Deferoxamine (1 mM; 16 h or 4 weeks) improves HIF-1α function under hypoxic and hyperglycemic conditions and decreases ROS in MEFs cells^[1].
Deferoxamine (100 μM; 24 h) increases InsR expression and activity and also induces an increase in p-Akt/total Akt/PKB levels^[2].
Deferoxamine (5, 10, 25, 50, 100 μM; 7 or 9 days) inhibits the proliferation of tumor-associated MSCs and bone marrow MSCs^[3].
Deferoxamine (5, 10, 25, 50, 100 μM; 7 days) induces apoptosis of MSCs^[3].
Deferoxamine (10 μM ; 3 days) influencs the expression of adhesion proteins on MSCs^[3].
Deferoxamine (100 μM; 24 h) induces autophagy mediated by the level of HIF-1α in SH-SY5Y cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MEFs cells
Concentration:

1 mM
Incubation Time:

16 h (hypoxia condition); 4 weeks (hyperglycemic conditions)
Result:

Significantly attenuated the hyperglycemia-associated increase in ROS levels under hypoxic high glucose conditions.
Notably increased normoxic HIF transactivation in MEFs under both high glucose and normal glucose conditions.

Western Blot Analysis^[2]

Cell Line:

HepG2 cells
Concentration:

100 µM
Incubation Time:

24 h
Result:

Showed a twofold increase of InsR mRNA levels in cells.
Increased by twofold InsR binding activity at the half-maximal concentration of 1.1 nM.

Cell Proliferation Assay^[3]

Cell Line:

TAMSCs and BMMSCs (all isolated from Male C57BL/6J mice (8 week-old; EG-7 induced tumor model))
Concentration:

5, 10, 25, 50, 100 µM
Incubation Time:

7 days (TAMSCs); 9 days (BMMSCs).
Result:

Inhibited the growth of TAMSCs and BMMSCs, and most cells are died at day 7 or 9 when exposed to 50 and 100 µM dose.

Apoptosis Analysis^[3]

Cell Line:

TAMSCs, BMMSCs
Concentration:

5, 10, 25, 50, 100 µM
Incubation Time:

7 days
Result:

Exhibited proapoptotic effect on TAMSCs and BMMSCs cells.

Western Blot Analysis^[3]

Cell Line:

TAMSCs, BMMSCs
Concentration:

10 µM
Incubation Time:

3 days
Result:

Remarkably decreased VCAM-1 expression in both TAMSCs and BMMSCs.

Cell Autophagy Assay^[4]

Cell Line:

SH-SY5Y cells
Concentration:

100 µM
Incubation Time:

24 h
Result:

Increased the ratio of LC3-II/I, an indicator of autophagy, which effects were blocked when autophagy-related gene Beclin 1 was suppressed by Beclin 1 siRNA transfection.
Caused a time and dose-dependent increase of HIF-1a, accompanied by the induction of autophagy.

In Vivo

Deferoxamine (560.68 mg/per; drip-on; once daily for 21 days) enhances wound healing and increases neovascularization in aged or diabetic mice^[1].
Deferoxamine (200 mg/kg; i.p.; daily for 2 weeks) results in HIF-1α stabilization and increases glucose uptake, hepatic InsR expression, and signaling in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Aged (21-month-old) and diabetic (12-week-old) C57BL/6J mice (excisional wound model)^[1].
Dosage:

560.68 mg/per (10 uL of 1 mM)
Administration:

Drip-on; once daily for 21 days.
Result:

Displayed significantly accelerated healing and increased neovascularization in both aged and diabetic mice model.

Animal Model:

Male Sprague-Dawley rats (180-200 g)^[2].
Dosage:

200 mg/kg
Administration:

Intraperitoneal injection; daily for 2 weeks.
Result:

Significantly increased hepatic HIF-1α protein levels, InsR protein levels, as well as Akt/PKB and activated Akt/PKB were significantly higher in the liver.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 70-51-9
Appearance Solid
Molecular Weight 560.68
Formel C₂₅H₄₈N₆O₈
Color White to off-white
SMILES

O=C(N(CCCCCN)O)CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O
Synonyms

Deferoxamine B; Deferriferrioxamine B; Deferrioxamine
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (438)

All Bio/Physico-chemical AssayIFCell Proliferation/Viability AssayWBRT-PCR

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Journal Impact Factor

Signal Transduct Target Ther

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. [Abstract]

2020 May 8;5(1):51. PMID: 32382060

Deferoxamine purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2020 May 8;5(1):51. [Abstract]

Representative results of wound healing after the treatment with the combination of ferroptosis inhibitor DFO and erianin. The expression of EMT markers E-Cadherin and N-Cadherin are examined by western blotting.
Cell

Stabilizing MARCH7 as a ferro-guardian against ferroptosis. [Abstract]

2026 Jun 11;189(12):3553-3570.e30. PMID: 42049018
Cell Res

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. [Abstract]

2018 Dec;28(12):1171-1185. PMID: 30287942

Deferoxamine purchased from MedChemExpress. Usage Cited in: Cell Res. 2018 Dec;28(12):1171-1185. [Abstract]

The FTL- or FTH1-knockdown A375 cells are pretreated with or without DFO (50 μM) for 2 h before CCCP stimulation. The pyroptotic morphology and LDH release are indicated.
Adv Mater

Nanozyme-Reinforced Hydrogel Spray as a Reactive Oxygen Species-Driven Oxygenator to Accelerate Diabetic Wound Healing. [Abstract]

2025 Aug;37(34):e2504829. PMID: 40492891
Nat Cancer

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. [Abstract]

2025 May;6(5):768-785. PMID: 40108413
Nat Aging

Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy. [Abstract]

2025 Jul;5(7):1295-1316. PMID: 40579479

Deferoxamine purchased from MedChemExpress. Usage Cited in: Nat Aging. 2025 Jul;5(7):1295-1316. [Abstract]

The percentage of dead C2C12 cells under conditional medium stimulation with or without Deferoxamine-B (10 μM; 72 h) treatment. PI dye staining was employed to identify dead cells (n = 5).
Light Sci Appl

Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo. [Abstract]

2024 Oct 31;13(1):304. PMID: 39482292
Bioact Mater

Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. [Abstract]

2021 Nov 19;13:23-36. PMID: 35224289

Deferoxamine purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]

H1299 cells are treated with Curcumenol with or without Deferoxamine (DFO; 20 μM) for 24 h, and the cell viability is analyzed.

Deferoxamine purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Nov 19;13:23-36. [Abstract]

The expression of ferroptosis-related proteins in lung cancer cells is detected after Curcumenol treatment with or without Deferoxamine (DFO; 20 μM) by western blotting.
Cell Host Microbe

Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosis. [Abstract]

2026 Jan 14;34(1):35-51.e9. PMID: 41500222
Nat Cell Biol

Stress granules restrain ferroptosis by sequestering ferritin. [Abstract]

2026 Jun;28(6):1204-1218. PMID: 42174134
Nat Cell Biol

Full-length GSDME mediates pyroptosis independent from cleavage. [Abstract]

2024 Sep;26(9):1545-1557. PMID: 38997456
Bone Res

The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer. [Abstract]

2024 Aug 27;12(1):47. PMID: 39191757

Deferoxamine purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 27;12(1):47. [Abstract]

Cell death induced by HOXC10 inhibition plus TTI-101 cotreatment was rescued by ferroptosis inhibitors. Cells with or without knockdown of HOXC10 were pretreated with HOXC10 TTI-101 for 12 h and then treated the indicated cell death inhibitors (3-MA-1 mmol/L, Necrostatin-1-20 μmol/L, Ferrostatin-1-2 μmol/L, Z-VAD-FMK-10 μmol/L, Glutathione-1 mmol/L, Deferoxamine (DFO-100 μmol/L)) for an additional 72 h. Effect on ferroptosis inhibitors rescuing cell death was assessed by cell viability assays.
Autophagy

Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]

2026 Feb 15:1-19. PMID: 41612599
Autophagy

Autophagic regulation of ferroportin 1 induces developmental ferroptosis in rice blast. [Abstract]

2025 Dec;21(12):2867-2882. PMID: 40774826
Nat Commun

Serine inhibits granulosa cell ferroptosis to maintain ovarian function. [Abstract]

2026 Jan 21;17(1):1738. PMID: 41565641
Nat Commun

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes. [Abstract]

2025 Apr 1;16(1):3131. PMID: 40169595
Nat Commun

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma. [Abstract]

2025 Jan 31;16(1):1212. PMID: 39890789
Exp Mol Med

Methyl-CpG-binding domain 2 mitigates osteoarthritis through Steap3 promoter methylation and chondrocyte ferroptosis regulation. [Abstract]

2025 Nov;57(11):2629-2642. PMID: 41258082
ACS Nano

Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma. [Abstract]

2025 Jun 10;19(22):21105-21117. PMID: 40424612
ACS Nano

Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction. [Abstract]

2024 Jul 2;18(26):16790-16807. PMID: 38869479
J Adv Res

Renal tubular Nfe2l1 protect cisplatin-induced acute kidney injury via suppressing ACSL4-dependent ferroptosis. [Abstract]

2026 May 3:S2090-1232(26)00381-4. PMID: 42086188
J Adv Res

Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis. [Abstract]

2025 Aug:74:429-442. PMID: 39353531
J Adv Res

Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. [Abstract]

2025 Aug:74:589-607. PMID: 39353532
J Adv Res

SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice. [Abstract]

2025 May:71:369-381. PMID: 38797476
J Adv Res

Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments. [Abstract]

2025 Feb 8:S2090-1232(25)00107-9. PMID: 39929269
Cell Discov

Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma. [Abstract]

2025 Oct 7;11(1):81. PMID: 41057295
Redox Biol

The tryptophan metabolite 3-hydroxyanthranilic acid alleviates hyperoxia-induced bronchopulmonary dysplasia via inhibiting ferroptosis. [Abstract]

2025 May:82:103579. PMID: 40117887
Redox Biol

Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1. [Abstract]

2025 May:82:103597. PMID: 40107016
Redox Biol

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment. [Abstract]

2025 Feb:79:103460. PMID: 39657365
Redox Biol

Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors. [Abstract]

2024 Dec:78:103419. PMID: 39527862
Redox Biol

Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma. [Abstract]

2024 Oct:76:103328. PMID: 39216271
Redox Biol

LACTB suppresses liver cancer progression through regulation of ferroptosis. [Abstract]

2024 Sep:75:103270. PMID: 39047638
Redox Biol

Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis. [Abstract]

2024 Jun:72:103157. PMID: 38631119
Redox Biol

Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes. [Abstract]

2022 Jun:52:102320. PMID: 35462320
Redox Biol

T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2. [Abstract]

2022 Apr;50:102257. PMID: 35149342
Redox Biol

ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance. [Abstract]

2021 Jul:43:101977. PMID: 33905957
Redox Biol

miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. [Abstract]

2020 Jan:29:101402. PMID: 31926626
J Nanobiotechnology

Ag2Se quantum dots neurotoxicity: mitochondrial stress drives ferroptosis-dependent microglial inflammation. [Abstract]

2026 Apr 2;24(1):431. PMID: 41928263
J Nanobiotechnology

Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy. [Abstract]

2025 Oct 16;23(1):684. PMID: 41102809
J Nanobiotechnology

Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity. [Abstract]

2025 Feb 14;23(1):109. PMID: 39953537
Theranostics

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. [Abstract]

2020 Apr 6;10(11):5107-5119. PMID: 32308771

Deferoxamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Apr 6;10(11):5107-5119. [Abstract]

The cell death induced by the treatment with β-elemene and cetuximab in KRAS mutant CRC cells is almost completely blocked by treatment with ferroptosis rescue agents Deferoxamine (DFO; 20 nM; 24 h), Liproxstatin-1 (Lip-1) or Ferrostatin-1 (Fer-1).
Acta Pharm Sin B

2026 Mar 3.
Acta Pharm Sin B

2025 Oct 28.
Acta Pharm Sin B

High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming. [Abstract]

2025 Jul;15(7):3788-3804. PMID: 40698150

Deferoxamine purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jul;15(7):3788-3804. [Abstract]

The cell viability of 4T1 cells that received various treatments in the presence of different ferroptosis inhibitors including Fer-1, Deferoxamine (DFO:100 μM; 24 h), and VE.

Deferoxamine purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jul;15(7):3788-3804. [Abstract]

Deferoxamine (10 μM; 1 h). GSH content in HIFU-treated 4T1 cells at the same EEF value.

Deferoxamine purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jul;15(7):3788-3804. [Abstract]

Deferoxamine (10 μM; 1 h). ROS content in HIFU-treated 4T1 cells at the same EEF value.
Acta Pharm Sin B

Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer. [Abstract]

2025 Apr;15(4):2095-2113. PMID: 40486852
Genes Dis

Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke. [Abstract]

2024 Mar 8;11(6):101262. PMID: 39286656
Acta Pharm Sin B

An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing. [Abstract]

2023 Oct;13(10):4318-4336. PMID: 37799395
Acta Pharm Sin B

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer. [Abstract]

2021 Jun;11(6):1513-1525. PMID: 34221865

Deferoxamine purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2021 Jun;11(6):1513-1525. [Abstract]

Deferoxamine (DFO; 10 μM; 72 h) can markedly reverse the cell growth prevented by a2 in MGC-803 and MKN-45 cells.
J Exp Clin Cancer Res

Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m6A-dependent recognition of Nrf2 mRNA mediated by SND1. [Abstract]

2023 May 19;42(1):127. PMID: 37202791
J Exp Clin Cancer Res

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2. [Abstract]

2023 Jan 5;42(1):5. PMID: 36600258
J Exp Clin Cancer Res

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. [Abstract]

2021 Jun 23;40(1):206. PMID: 34162423

Deferoxamine purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2021 Jun 23;40(1):206. [Abstract]

Propidium iodide staining confirmed that DFO inhibited metformin-induced cell death in T47D cells Deferoxamine (20 μM; 48 h).
Adv Sci (Weinh)

Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis. [Abstract]

2026 Apr;13(19):e15768. PMID: 41589658
Adv Sci (Weinh)

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. [Abstract]

2026 Mar;13(16):e13310. PMID: 41589654
Adv Sci (Weinh)

Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2. [Abstract]

2026 Mar 18:e22690. PMID: 41849685
Adv Sci (Weinh)

Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke. [Abstract]

2026 Jan 25:e11482. PMID: 41580979
Adv Sci (Weinh)

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress-Induced Depression in Male Mice. [Abstract]

2025 Dec 12:e13438. PMID: 41387185
Adv Sci (Weinh)

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke. [Abstract]

2025 Nov 6:e07384. PMID: 41195589
Adv Sci (Weinh)

Fe-S Protein FDX1 Triggers Tumor-Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC. [Abstract]

2025 Nov 7:e18323. PMID: 41199656
Adv Sci (Weinh)

PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation. [Abstract]

2025 Jul 26:e02052. PMID: 40714837
Adv Sci (Weinh)

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer. [Abstract]

2025 Mar;12(12):e2408845. PMID: 39888307

Deferoxamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Mar;12(12):e2408845. [Abstract]

Deferoxamine (DFO) (50 µM; 24 h) significantly rescues promoted CRC cells death induced by different FINs.
MedComm

Antiferroptosis therapy alleviated the development of atherosclerosis. [Abstract]

2024 Apr 4;5(4):e520. PMID: 38576455
Adv Sci (Weinh)

Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer. [Abstract]

2023 Sep;10(25):e2301088. PMID: 37428466
Adv Sci (Weinh)

Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression. [Abstract]

2023 Aug;10(22):e2206798. PMID: 37330650
Adv Sci (Weinh)

The Imbalance of p53-Park7 Signaling Axis Induces Iron Homeostasis Dysfunction in Doxorubicin-Challenged Cardiomyocytes. [Abstract]

2023 May;10(15):e2206007. PMID: 36967569
Adv Sci (Weinh)

A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome. [Abstract]

2021 Mar 8;8(10):2004680. PMID: 34026460

Deferoxamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Mar 8;8(10):2004680. [Abstract]

Deferoxamine (DFO; 0.5 μM; for 48 h) could rescue iron overload‐induced cell death in both iHep‐Orgs and iHep.

Deferoxamine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2021 Mar 8;8(10):2004680. [Abstract]

Deferoxamine ( 0.5 µM; 48 h) can rescue iron overload‐induced cell death in both iHep‐Orgs and iHep.
Cell Rep Med

Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis. [Abstract]

2025 Sep 25:102371. PMID: 41005298
Sci Adv

Iron deficiency-induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modification. [Abstract]

2023 Nov 15;9(46):eadf4345. PMID: 37976359
Sci Adv

PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients. [Abstract]

2022 Mar 4;8(9):eabm1896. PMID: 35235351

Deferoxamine purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Mar 4;8(9):eabm1896. [Abstract]

PAI1 mRNA expression in iHUVEC treated with increasing doses of either CoCl2, Deferoxamine (DFO), 1, 4-DPCA or DMOG.
Cell Death Differ

Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. [Abstract]

2026 Jun 3. PMID: 42236908
Cell Death Differ

MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer. [Abstract]

2025 Dec 19. PMID: 41420103
Cell Death Differ

Inhibition of ferroptosis counteracts the advanced maternal age-induced oocyte deterioration. [Abstract]

2025 Jun;32(6):1071-1085. PMID: 39910323
Cell Death Differ

ATOH8 confers the vulnerability of tumor cells to ferroptosis by repressing SCD expression. [Abstract]

2025 Mar 25. PMID: 40133667
Carbohydr Polym

Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy. [Abstract]

2025 Mar 1:351:123123. PMID: 39779030
Carbohydr Polym

Deferoxamine functionalized alginate-based collagen composite material enhances the integration of metal implant and bone interface. [Abstract]

2025 Feb 1;349(Pt A):122944. PMID: 39643405
Chem Eng J

2026 Jan 15;529:173043.
J Control Release

Hydrogel-immobilized coacervate droplets enable microenvironment-responsive sustained drug release to accelerate diabetic foot ulcers healing. [Abstract]

2026 Jun 10:394:114858. PMID: 41881075
J Control Release

In situ delivery of JPH203 via camptothecin-peptide conjugate nanoassemblies to trigger ferroptosis in triple-negative breast cancer. [Abstract]

2026 May 10:393:114829. PMID: 41839266
J Control Release

Inducing potent ferroptosis in cancer cells by manipulation of ferritinophagy with a ferritin-targeted ATTEC. [Abstract]

2026 Jan 10:389:114450. PMID: 41274571
Environ Sci Technol

Iron-Rich Particles Drive Pulmonary Toxicity of Coal Combustion-Derived Fine Particles via Transferrin Receptor-Mediated Ferroptosis. [Abstract]

2026 Mar 17;60(10):7716-7732. PMID: 41766572
Cell Death Dis

Liver kinase B1 maintains natural killer cell survival by regulating redox homeostasis. [Abstract]

2026 Mar 27;17(1):413. PMID: 41896546
Cell Death Dis

Targeting the SMAD3/CISD2 axis suppresses bladder cancer progression by promoting ferroptosis in mesenchymal-like bladder cancer cells. [Abstract]

2025 Dec 18. PMID: 41413023
Environ Sci Technol

Bisphenol A Disrupts Spermatogenesis via Excessive Mitophagy-Driven Ferroptosis. [Abstract]

2025 Oct 28;59(42):22423-22438. PMID: 41104744
Cell Death Dis

A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP. [Abstract]

2025 May 19;16(1):403. PMID: 40389408
Cell Death Dis

Depletion of the N6-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4. [Abstract]

2024 Mar 1;15(3):181. PMID: 38429265
Cell Death Dis

LINC01133 can induce acquired ferroptosis resistance by enhancing the FSP1 mRNA stability through forming the LINC01133-FUS-FSP1 complex. [Abstract]

2023 Nov 25;14(11):767. PMID: 38007473
Cell Death Dis

Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer. [Abstract]

2023 Sep 4;14(9):588. PMID: 37666806
Cell Death Dis

Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma. [Abstract]

2023 Mar 25;14(3):211. PMID: 36966152
Cell Death Dis

SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase. [Abstract]

2023 Jan 12;14(1):22. PMID: 36635256
Cell Death Dis

UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes. [Abstract]

2022 Dec 24;13(12):1070. PMID: 36566325
Cell Death Dis

Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity. [Abstract]

2022 Jul 4;13(7):579. PMID: 35787614
Cell Death Dis

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. [Abstract]

2022 Jul 28;13(7):653. PMID: 35902564
Pharmacol Res

Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer. [Abstract]

2021 Aug:170:105701. PMID: 34087353
Cell Death Dis

MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. [Abstract]

2021 May 19;12(6):511. PMID: 34011924
Cell Death Dis

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. [Abstract]

2021 Apr 30;12(5):426. PMID: 33931597
Cell Death Dis

"Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis. [Abstract]

2020 Mar 13;11(3):183. PMID: 32170066
Cell Death Dis

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. [Abstract]

2019 Oct 7;10(10):755. PMID: 31591388
Cell Death Dis

Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. [Abstract]

2019 Apr 15;10(5):331. PMID: 30988278
Cancer Lett

Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma. [Abstract]

2024 May 1:589:216811. PMID: 38490328
Cancer Lett

Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization. [Abstract]

2024 Apr 10:587:216732. PMID: 38360142
J Immunother Cancer

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma. [Abstract]

2024 Nov 24;12(11):e009805. PMID: 39581704
Int J Biol Sci

IL-6 signaling accelerates iron overload by upregulating DMT1 in endothelial cells to promote aortic dissection. [Abstract]

2024 Aug 6;20(11):4222-4237. PMID: 39247821
Cell Commun Signal

Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development. [Abstract]

2022 Aug 17;20(1):124. PMID: 35978430
Phytomedicine

5-O-Methylembelin disrupts the ACO1-TPI1 interaction to promote ferroptosis in clear cell renal cell carcinoma. [Abstract]

2026 May 14:157:158282. PMID: 42166976
Phytomedicine

Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells. [Abstract]

2026 May:154:158057. PMID: 41833103
Phytomedicine

Tongguanteng injection induces cell cycle arrest and drives ferroptosis through AURKA/KEAP1/NRF2 axis in breast cancer. [Abstract]

2026 Apr 27. PMID: 42105703
Phytomedicine

Licochalcone B targets neural cell adhesion molecule 1 to inhibit osteosarcoma progression and ferroptosis resistance via extracellular signal-regulated kinase 5 and nuclear factor kappa B pathways. [Abstract]

2026 Jan:150:157584. PMID: 41349457
Phytomedicine

Tripterygium glycosides reverse cisplatin resistance in epithelial ovarian cancer by activating ferroptosis via two different pathways. [Abstract]

2026 Mar:152:157865. PMID: 41619560
Phytomedicine

Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via NF-κB pathway inhibition. [Abstract]

2026 Jan:150:157633. PMID: 41351983
Phytomedicine

Astragali radix - Curcumae rhizoma herb pair enhances Sorafenib's efficacy by inducing ferroptosis and activates Th1 cell immune response synergistically against hepatocellular carcinoma. [Abstract]

2025 Sep 23:148:157326. PMID: 41016296
Phytomedicine

The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis. [Abstract]

2025 Jul:142:156804. PMID: 40311597
Phytomedicine

Picropodophyllin induces ferroptosis via blockage of AKT/NRF2/SLC7A11 and AKT/NRF2/SLC40A1 axes in hepatocellular carcinoma as a natural IGF1R inhibitor. [Abstract]

2025 Jul 25:143:156840. PMID: 40412057
Phytomedicine

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis. [Abstract]

2025 Apr:139:156417. PMID: 39923427
Phytomedicine

Erianin triggers ferroptosis in colorectal cancer cells by facilitating the ubiquitination and degradation of GPX4. [Abstract]

2025 Apr:139:156465. PMID: 39938177
Phytomedicine

Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression. [Abstract]

2024 Dec:135:156195. PMID: 39488871
Phytomedicine

Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis. [Abstract]

2024 Dec:135:156139. PMID: 39423479
Phytomedicine

6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species. [Abstract]

2022 May 13;102:154164. PMID: 35597026
Phytomedicine

Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. [Abstract]

2021 May:85:153551. PMID: 33827043
Phytomedicine

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. [Abstract]

2021 Jan:80:153370. PMID: 33113504
J Pharm Anal

Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor. [Abstract]

2023 Jan;13(1):99-109. PMID: 36816538
EBioMedicine

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis. [Abstract]

2022 Oct;84:104258. PMID: 36137413
EBioMedicine

Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression. [Abstract]

2022 Feb;76:103847. PMID: 35101656
Chin Herb Med

Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition. [Abstract]

2020 Dec 8;13(1):105-115. PMID: 36117765
Mater Today Bio

NIR-elicited nanoplatform amplifies cancer ferrotherapy in uveal melanoma via synergistic ferroptosis induction and glucose metabolism intervention. [Abstract]

2026 May 6:38:103208. PMID: 42170235
Burns Trauma

2026 Jan 13.
Mater Today Bio

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse. [Abstract]

2025 Nov 13:35:102547. PMID: 41322137
J Hazard Mater

HFPO-TA inhibits testosterone synthesis by triggering FTO-mediated m6A modification to drive NCOA4-associated ferroptosis. [Abstract]

2026 Jun 16:514:142733. PMID: 42314315
J Hazard Mater

TDCIPP disrupts decidual macrophage function to induce miscarriage through ferroptosis-mediated DNA damage. [Abstract]

2026 Feb 15:504:141271. PMID: 41610664
J Hazard Mater

m6A modification of ATG9A regulates ferritinophagy in microglial activation induced by arsenic. [Abstract]

2025 Sep 15:496:139376. PMID: 40816185
J Hazard Mater

Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation. [Abstract]

2024 Dec 5:480:135952. PMID: 39341193
J Hazard Mater

The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage. [Abstract]

2022 Aug 15;436:129043. PMID: 35525219

Deferoxamine purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2022 Aug 15;436:129043. [Abstract]

The specific inhibitor of ferroptosis Fer-1 (100 μM) and Lip-1 (5 μM), and the iron chelator Deferoxamine (DFOM;100 μM) restored the cellular activity of RAW264.7 macrophages after treatment for 24 h.

Deferoxamine purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2022 Aug 15;436:129043. [Abstract]

Deferoxamine (DFOM; 100 μM; 24 h) attenuated the abnormal increase of ROS and LPO in macrophages elicited by CdTe QDs.
Acta Pharmacol Sin

YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease. [Abstract]

2025 Jul;46(7):1974-1989. PMID: 40038466
Cell Death Discov

Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis. [Abstract]

2025 Feb 21;11(1):71. PMID: 39984437
Cell Death Discov

Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content. [Abstract]

2024 Aug 12;10(1):360. PMID: 39134539
Cell Death Discov

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis. [Abstract]

2024 Jan 17;10(1):34. PMID: 38233385
Cell Death Discov

Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway. [Abstract]

2023 Nov 18;9(1):419. PMID: 37980349
Cell Death Discov

Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice. [Abstract]

2022 Apr 21;8(1):217. PMID: 35449198
Cell Death Discov

Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model. [Abstract]

2022 Mar 22;8(1):127. PMID: 35318301
Acta Pharmacol Sin

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Feb;42(2):301-310. PMID: 32699265
Acta Pharmacol Sin

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma. [Abstract]

2021 Jan;42(1):160-170. PMID: 32541921
NPJ Precis Oncol

Targeting Nrf2/PHKG2 axis to enhance radiosensitivity in NSCLC. [Abstract]

2024 Aug 21;8(1):183. PMID: 39169204
J Transl Med

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis. [Abstract]

2025 Feb 28;23(1):247. PMID: 40022222
J Colloid Interface Sci

Interfacial strong interaction-enabling cascade nanozymes for apoptosis-ferroptosis synergistic therapy. [Abstract]

2024 Jan;653(Pt A):20-29. PMID: 37708728
Nano Res

2025 Oct.
Mater Today Phys

2023 Aug, 36, 101150.
Oncogene

CAPRIN1-mediated sequestration of NCOA4 mRNA into stress granules drives sorafenib resistance in hepatocellular carcinoma. [Abstract]

2026 May;45(16):1411-1424. PMID: 41896589
Apoptosis

Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation. [Abstract]

2024 Oct;29(9-10):1810-1823. PMID: 38704789
Int J Biol Macromol

Rbbp7-mediated deacetylation of Acsl4 promotes ovarian aging by enhancing ferroptosis. [Abstract]

2025 Dec 30;339(Pt 2):149976. PMID: 41478474
Int J Biol Macromol

Chitosan oligosaccharides alleviate macrophage pyroptosis and protect sepsis mice via activating the Nrf2/GPX4 pathway. [Abstract]

2024 Oct;277(Pt 1):133899. PMID: 39019361
Int J Biol Macromol

Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing. [Abstract]

2022 Mar 31:202:657-670. PMID: 35066024
Mol Ther Oncol

Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth. [Abstract]

2025 Apr 14;33(2):200983. PMID: 40343114
Int J Mol Med

Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells. [Abstract]

2022 Feb;49(2):17. PMID: 34935058
Int J Mol Med

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. [Abstract]

2021 Apr;47(4):61. PMID: 33649797
EMBO J

A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress. [Abstract]

2023 Oct 16;42(20):e113743. PMID: 37661833
Mol Med

MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis. [Abstract]

2024 Nov 5;30(1):199. PMID: 39501138
Mol Med

Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation. [Abstract]

2024 Jun 12;30(1):83. PMID: 38867145
Antioxidants (Basel)

Hypoxia-Inducible Factor 1α Affects Yak Oocyte Maturation and Early Embryonic Development by Regulating Autophagy. [Abstract]

2024 Jul 14;13(7):840. PMID: 39061908
Antioxidants (Basel)

Dysregulation of Ceramide Metabolism Is Linked to Iron Deposition and Activation of Related Pathways in the Aorta of Atherosclerotic Miniature Pigs. [Abstract]

2023 Dec 19;13(1):4. PMID: 38275624
Antioxidants (Basel)

Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries. [Abstract]

2023 Dec 15;12(12):2119. PMID: 38136238
Phytother Res

Fisetin Promotes Autophagy in Osteosarcoma by Activating the ROS/FOXO3 Axis via Oxidative Stress. [Abstract]

2026 Jul;40(7):4384-4403. PMID: 42093580
Phytother Res

Quercetin Overcomes Cisplatin Resistance by Inducing Ferroptosis via the DDB2-AS1/miR-4728-5p/p53 Axis. [Abstract]

2026 Mar;40(3):1230-1251. PMID: 41562315
Free Radic Biol Med

Rab26 mitigates ferroptosis in airway epithelium induced by cigarette smoke through suppression of VDAC1 oligomerization-mediated cGAS-STING activation. [Abstract]

2026 Sep:253:177-194. PMID: 42176907
Free Radic Biol Med

DLAT sustains redox homeostasis and prevent colorectal cancer from ferroptosis by regulating SLC25A39-mediated mitochondrial glutathione transport. [Abstract]

2026 Aug 1:251:229-242. PMID: 42009144
Free Radic Biol Med

Stabilization of Keap1 by alkannin triggers ferroptotic cell death in colorectal cancer via suppression of the Nrf2/GPX4 signaling. [Abstract]

2026 Jun 23:254:342-359. PMID: 42336003
Free Radic Biol Med

Ginsenoside Rk1 suppresses osteosarcoma progression by coordinately activating ferritinophagy and disrupting antioxidant defense to induce ferroptosis. [Abstract]

2026 Jun 27:S0891-5849(26)00907-X. PMID: 42364854
Free Radic Biol Med

Baicalin triggers ferroptosis to suppress colorectal cancer via SLC25A28-UQCRC2-regulated electron transport chain disruption. [Abstract]

2025 Dec 26:245:56-70. PMID: 41456814
Free Radic Biol Med

Cadmium induces ferroptosis in B cells via ATP6V0A1-upregulated lysosomal ferritinophagy: insights from murine transcriptomics and human cellular models. [Abstract]

2025 Oct 27:S0891-5849(25)01318-8. PMID: 41161393
Free Radic Biol Med

Ferulic acid attenuates Sarcopenia progression by inhibiting peroxisomal ACOX1. [Abstract]

2025 Aug 13:240:183-196. PMID: 40816648
Free Radic Biol Med

Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]

2025 Aug 1:235:231-247. PMID: 40316059
Free Radic Biol Med

Lithium Enhances Ferroptosis sensitivity in melanoma cells and promotes CD8+ T Cell infiltration and differentiation. [Abstract]

2025 Feb 1:227:233-245. PMID: 39645207
Free Radic Biol Med

LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: Induction of Metallothionein-1 and suppression of tubular ferroptosis. [Abstract]

2024 Oct:223:42-52. PMID: 39033829
Free Radic Biol Med

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis. [Abstract]

2024 Sep:222:344-360. PMID: 38945457
Free Radic Biol Med

Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis. [Abstract]

2023 Dec 14:211:127-144. PMID: 38103660
Free Radic Biol Med

STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. [Abstract]

2023 Nov 1:208:348-360. PMID: 37634745
Free Radic Biol Med

Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction. [Abstract]

2023 Sep:206:143-161. PMID: 37392951
Free Radic Biol Med

Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression. [Abstract]

2023 Nov 1:208:530-544. PMID: 37717793
Free Radic Biol Med

Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway. [Abstract]

2023 May 20:201:76-88. PMID: 36933812
Free Radic Biol Med

Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction. [Abstract]

2023 Apr:199:67-80. PMID: 36805044
Free Radic Biol Med

Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase. [Abstract]

2022 Nov 20;193(Pt 1):202-212. PMID: 36228830
Free Radic Biol Med

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation. [Abstract]

2022 Aug 1:188:337-350. PMID: 35752374
Free Radic Biol Med

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4. [Abstract]

2022 Feb 20:180:75-84. PMID: 35038550
Free Radic Biol Med

Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway. [Abstract]

2022 Feb 20:180:95-107. PMID: 35045311
Free Radic Biol Med

Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. [Abstract]

2021 Sep:173:29-40. PMID: 34246777
Free Radic Biol Med

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis. [Abstract]

2021 Jun:169:271-282. PMID: 33895289
Free Radic Biol Med

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. [Abstract]

2020 Nov 20:160:303-318. PMID: 32846217
Free Radic Biol Med

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell. [Abstract]

2020 Nov 20:160:92-102. PMID: 32768568
Clin Transl Med

Selective cargo sorting in stem cell-derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration. [Abstract]

2023 Dec;13(12):e1494. PMID: 38037469
Am J Chin Med

Cepharanthine Triggers Ferroptosis in Gastric Cancer by PINK1/FUNDC1-Mediated Mitophagy-Dependent GPX4 Degradation. [Abstract]

2026;54(1):329-348. PMID: 41684093
ACS Appl Mater Interfaces

Noninvasive and Precise Transdermal Drug Delivery Using Spatiotemporally Responsive Lipid Vesicles in Conjunction with Ultrasound. [Abstract]

2025 Aug 13;17(32):45463-45478. PMID: 40758320
Am J Chin Med

Puerarin Attenuates Myocardial Ischemia-Reperfusion Damage by Targeting Ferroptosis through 14-3-3η Modulation. [Abstract]

2025;53(5):1501-1520. PMID: 40646505
Am J Chin Med

Panax notoginseng Saponins Activate Nuclear Factor Erythroid 2-Related Factor 2 to Inhibit Ferroptosis and Attenuate Inflammatory Injury in Cerebral Ischemia-Reperfusion. [Abstract]

2024;52(3):821-839. PMID: 38699996
ACS Appl Mater Interfaces

Enzymatic Formation of an Injectable Hydrogel from a Glycopeptide as a Biomimetic Scaffold for Vascularization. [Abstract]

2018 Feb 21;10(7):6180-6189. PMID: 29380599

Deferoxamine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2018 Feb 21;10(7):6180-6189. [Abstract]

Quantitative analyses confirm the steady increase of blood vessels over the course of implantation of DFO-loading Gp gel.
Cell Rep

The xCT/CD98 complex suppresses ferroptosis in pan-cancer via a non-canonical RACK1-mediated iron homeostasis pathway. [Abstract]

2025 Nov 25;44(11):116563. PMID: 41252251
Cell Rep

Pp1-87B/PPP1CC-JNK axis integrates apoptosis and ferroptosis-like cell death to regulate cell competition and tumorigenesis. [Abstract]

2025 Sep 3;44(9):116240. PMID: 40906558
Cell Rep

TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation. [Abstract]

2025 Aug 21;44(9):116186. PMID: 40844875
Br J Pharmacol

The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination. [Abstract]

2024 Dec;181(23):4822-4844. PMID: 39228119
Br J Pharmacol

IDH2-NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis. [Abstract]

2024 Oct;181(20):4067-4084. PMID: 39072736
Neurotherapeutics

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. [Abstract]

2020 Oct;17(4):1796-1812. PMID: 32959272
Environ Health

2025 Nov 28，XXXX(XXX).
J Med Chem

Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy. [Abstract]

2019 Oct 10;62(19):8760-8772. PMID: 31509699
Environ Pollut

Methylmercury induced ferroptosis by interference of iron homeostasis and glutathione metabolism in CTX cells. [Abstract]

2023 Oct 15:335:122278. PMID: 37517642
Environ Pollut

Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice. [Abstract]

2023 May 15:325:121434. PMID: 36907243
Environ Pollut

PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance. [Abstract]

2019 Nov;254(Pt A):112937. PMID: 31401526
Cancer Cell Int

Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy. [Abstract]

2024 Jun 3;24(1):194. PMID: 38831301
Redox Rep

The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress. [Abstract]

2025 Dec;30(1):2588086. PMID: 41292488
J Ethnopharmacol

Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. [Abstract]

2026 Oct 28:369:121932. PMID: 42219071
Virulence

Klebsiella pneumoniae induced ferroptosis by inhibition of the Nrf2/xCT/GPX4 pathway in bovine mastitis: In vivo and in vitro. [Abstract]

2025 Dec;16(1):2600142. PMID: 41343264
J Ethnopharmacol

Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy. [Abstract]

2025 Jun 26:350:120055. PMID: 40441459
J Ethnopharmacol

Astragali radix - Curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR/AKT/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1α/HO-1/GPX4 axis. [Abstract]

2025 May 28:348:119912. PMID: 40316156
Hum Reprod

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. [Abstract]

2021 Mar 18;36(4):951-964. PMID: 33378529
J Agric Food Chem

Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification. [Abstract]

2026 Apr 29;74(16):13162-13178. PMID: 41906758
J Agric Food Chem

Polystyrene Microplastics Induced Hepatocytes Pyroptosis, Apoptosis and Ferroptosis via GSDMD-N-Mediated Mitochondrial Damage. [Abstract]

2026 Apr 29;74(16):13213-13229. PMID: 41980172
Talanta

In vitro assessment of ferroptosis of cells exposed to cigarette smoke aerosol using a self-designed on-chip evaluation system based on gas-liquid dual-dimensional exposure. [Abstract]

2024 Sep 1:277:126352. PMID: 38838566
J Agric Food Chem

Sodium Sulfite-Triggered Hepatocyte Ferroptosis via mtROS/Lysosomal Membrane Permeabilization-Mediated Lysosome Iron Efflux. [Abstract]

2023 Nov 1;71(43):16310-16322. PMID: 37871339
J Agric Food Chem

Patulin Induces Acute Kidney Injury in Mice through Autophagy-Ferroptosis Pathway. [Abstract]

2022 May 25;70(20):6213-6223. PMID: 35543324
Ecotoxicol Environ Saf

Curcumin alleviates BPAF-induced ferroptosis in caprine endometrial epithelial cells through inhibition of endoplasmic reticulum stress and autophagy. [Abstract]

2026 May 14:318:120253. PMID: 42134007
Ecotoxicol Environ Saf

Lycopene inhibits zearalenone-induced ferroptosis via activating AMPK/Nrf2 signaling pathway in AML-12 hepatocytes and in mice livers. [Abstract]

2025 Sep 15:303:119045. PMID: 40945091
Ecotoxicol Environ Saf

Autophagy-mediated ferroptosis involved in nickel-induced nephrotoxicity in the mice. [Abstract]

2023 Jul 1:259:115049. PMID: 37235900
Ecotoxicol Environ Saf

PM2.5 exposure triggers cell death through lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells. [Abstract]

2022 Dec 15:248:114333. PMID: 36446170
Biochem Pharmacol

ZFP36 inhibits trophoblast ferroptosis and attenuates preeclampsia development by promoting NCOA4 mRNA degradation and suppressing ferritinophagy. [Abstract]

2026 Jun:248:117836. PMID: 41765113
Biochem Pharmacol

Overexpression of GJB1-13k induces mitochondrial calcium overload and triggers apoptosis and GSDME-mediated pyroptosis in cervical cancer. [Abstract]

2026 May 16:118073. PMID: 42144203
Biochem Pharmacol

PFKFB4-Mediated HSPB1 phosphorylation suppresses ferroptosis to Promote gastric cancer progression. [Abstract]

2026 Apr:246:117714. PMID: 41577048
Biochem Pharmacol

Imperatorin induces ferroptosis via mediating lipid peroxidation and SLC7A11/ACSL4/GPX4 signaling for inhibition and therapeutics of prostate cancer. [Abstract]

2026 Mar:245:117683. PMID: 41506540
Biochem Pharmacol

Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells. [Abstract]

2025 Mar:233:116763. PMID: 39832669
Biochem Pharmacol

Inhibition of ferroptosis protects intrahepatic bile duct cells against ischemia-reperfusion and bile salt toxicity. [Abstract]

2025 Mar:233:116788. PMID: 39890033
Biochem Pharmacol

Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. [Abstract]

2024 May:223:116194. PMID: 38583812
Cell Mol Life Sci

Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1. [Abstract]

2023 May 20;80(6):159. PMID: 37209177
Cell Mol Life Sci

Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway. [Abstract]

2022 Jul 4;79(7):394. PMID: 35786773
Biochem Pharmacol

Eltrombopag inhibits Type I interferon-mediated antiviral signaling by decreasing cellular iron. [Abstract]

2021 Apr:186:114436. PMID: 33539815
J Bone Miner Res

Disorder of Iron Metabolism Inhibits the Recovery of Unloading-Induced Bone Loss in Hypomagnetic Field. [Abstract]

2020 Jun;35(6):1163-1173. PMID: 31880821

Deferoxamine purchased from MedChemExpress. Usage Cited in: J Bone Miner Res. 2020 Jun;35(6):1163-1173. [Abstract]

The expression of iron metabolism related protein is assessed by western blot. Protein levels of FPN1 and hepcidin1 in the liver. BL: The baseline group, mice are raised with under the GMF for 4 weeks. HLU: Mice hindlimb are unloaded and raised for 4 weeks. GMF: Mice are kept in a wooden experimental box with the normal GMF for 8 weeks. HyMF: Mice are raised in a GMF-shielded room for 8 weeks. HLU+GMF: HLU mice are reloaded and raised in a wooden box for 4 weeks. HLU+HyMF: HLU mice are reloaded

Deferoxamine purchased from MedChemExpress. Usage Cited in: J Bone Miner Res. 2020 Jun;35(6):1163-1173. [Abstract]

The expression of iron metabolism related protein was assessed by western blot. Protein levels of TfR1, FTH1 and FPN1 in the tibia. BL: The baseline group, mice are raised with under the GMF for 4 weeks. HLU: Mice hindlimb are unloaded and raised for 4 weeks. GMF: Mice are kept in a wooden experimental box with the normal GMF for 8 weeks. HyMF: Mice are raised in a GMF-shielded room for 8 weeks. HLU+GMF: HLU mice are reloaded and raised in a wooden box for 4 weeks. HLU+HyMF: HLU mice are reloade
Life Sci

Aging-associated GSK3β overexpression exacerbates hepatic ischemia-reperfusion injury through Nrf2 deficiency-induced hepatocyte ferroptosis. [Abstract]

2026 Mar 1:388:124214. PMID: 41548594
Life Sci

FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells. [Abstract]

2020 Nov 1:260:118077. PMID: 32810509
Life Sci

Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. [Abstract]

2020 Apr 15:247:117425. PMID: 32057904
Mol Cell Proteomics

Sulconazole induces PANoptosis by triggering oxidative stress and inhibiting glycolysis to increase radiosensitivity in esophageal cancer. [Abstract]

2023 Jun;22(6):100551. PMID: 37076047
Liver Int

Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy. [Abstract]

2022 Dec;42(12):2889-2899. PMID: 36254713
Liver Int

Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. [Abstract]

2020 Jun;40(6):1378-1394. PMID: 32145145
Transl Res

Puerarin inhibits Benign prostatic hyperplasia through regulating HIF-1α-HIF-1β/ AKT1/AP-1. [Abstract]

2026 Jun:292:1-13. PMID: 41962629
Anal Chim Acta

A signal-off fluorescent strategy for deferasirox effective detection using carbon dots as probe and Cu2+ as medium. [Abstract]

2021 Sep 22:1179:338853. PMID: 34535261
Drug Des Devel Ther

Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells. [Abstract]

2019 Jul 2:13:2135-2144. PMID: 31456633
Surf Interfaces

2025 Sep 1.
Int J Pharm

Fibroin nanodisruptor with Ferroptosis-Autophagy synergism is potent for lung cancer treatment. [Abstract]

2024 Oct 25:664:124582. PMID: 39142466
Int J Pharm

Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells. [Abstract]

2019 Dec 15:572:118782. PMID: 31678528
Colloids Surf B Biointerfaces

Arginine tagged liposomal carrier for the delivery of celastrol for ferroptosis-induced hepatocellular carcinoma therapy. [Abstract]

2025 Jun:250:114546. PMID: 39919344
Cancer Nanotechnol

2023 Oct 21.
Eur J Pharmacol

Arctiin attenuated NASH by inhibiting glycolysis and inflammation via FGFR2/CSF1R signaling. [Abstract]

2025 Jun 5:996:177424. PMID: 40010483
Eur J Pharmacol

ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway. [Abstract]

2024 Apr 15:969:176303. PMID: 38211715
Eur J Pharmacol

Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. [Abstract]

2023 Oct 15:957:176009. PMID: 37619784
Eur J Pharmacol

Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis. [Abstract]

2023 Apr 5:944:175516. PMID: 36758783
Eur J Pharmacol

Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. [Abstract]

2023 Mar 15:943:175569. PMID: 36740037
Eur J Pharmacol

Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis. [Abstract]

2021 May 5:898:173999. PMID: 33675785
Int J Mol Sci

Uric Acid Induces Hepatocytes Ferroptosis Through HIF-2α/DMT1-Mediated Iron Overload. [Abstract]

2026 Mar 20;27(6):2833. PMID: 41898692
Int Immunopharmacol

Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. [Abstract]

2025 Jun 17:158:114827. PMID: 40359890
Int Immunopharmacol

Targeting NFE2L2/GPX4 signaling pathway: Therapeutic potential of arsenic sulfide-induced ferroptosis in combating rhabdomyosarcoma. [Abstract]

2024 Nov 14;143(Pt 3):113614. PMID: 39547014
Int Immunopharmacol

CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1. [Abstract]

2024 Nov 13;143(Pt 3):113617. PMID: 39541845
Int J Mol Sci

Nicotinamide Mononucleotide (NMN) Ameliorates Free Fatty Acid-Induced Pancreatic β-Cell Dysfunction via the NAD+/AMPK/SIRT1/HIF-1α Pathway. [Abstract]

2024 Sep 30;25(19):10534. PMID: 39408861
Int J Mol Sci

The Tumor Microenvironment Mediates the HIF-1α/PD-L1 Pathway to Promote Immune Escape in Colorectal Cancer. [Abstract]

2024 Mar 27;25(7):3735. PMID: 38612546
Int J Mol Sci

Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis. [Abstract]

2024 Feb 20;25(5):2458. PMID: 38473706
Int J Mol Sci

Pan-Inhibition of Protein Disulfide Isomerase Caused Cell Death through Disrupting Cellular Proteostasis in Pancreatic Ductal Adenocarcinoma Cells. [Abstract]

2023 Nov 17;24(22):16467. PMID: 38003657
Int J Mol Sci

Evaluation of the Combined Effect of Artemisinin and Ferroptosis Inducer RSL3 against Toxoplasma gondii. [Abstract]

2022 Dec 23;24(1):229. PMID: 36613672
Biol Direct

NSDHL as a regulator of lipid peroxidation and ER stress-mediated apoptosis in ovarian cancer. [Abstract]

2026 Apr 8;21(1):68. PMID: 41952197
Biol Direct

MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1. [Abstract]

2025 Oct 1;20(1):100. PMID: 41035046
Mol Neurobiol

ROS Regulate Rotenone-induced SH-SY5Y Dopamine Neuron Death Through Ferroptosis-mediated Autophagy and Apoptosis. [Abstract]

2025 Jul;62(7):9271-9289. PMID: 40097764
Mol Neurobiol

Stress-mediated Activation of Ferroptosis, Pyroptosis, and Apoptosis Following Mild Traumatic Brain Injury Exacerbates Neurological Dysfunctions. [Abstract]

2025 Apr;62(4):4055-4075. PMID: 39388040
Biol Direct

Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma. [Abstract]

2024 Nov 11;19(1):110. PMID: 39529192
Front Cell Infect Microbiol

Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis. [Abstract]

2022 Feb 4;12:825824. PMID: 35186798
Front Pharmacol

Pomolic acid induces ferroptosis-mediated cell death in non-small cell lung cancer. [Abstract]

2025 Jun 4:16:1567942. PMID: 40535769
Inflammation

Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury. [Abstract]

2025 May 13. PMID: 40358793
mBio

The long noncoding RNA APR attenuates PPRV infection-induced accumulation of intracellular iron to inhibit membrane lipid peroxidation and viral replication. [Abstract]

2025 Apr 9;16(4):e0012725. PMID: 40126010
Front Pharmacol

β-Elemene promotes ferroptosis and reverses radioresistance in gastric cancer by inhibiting the OTUB1-GPX4 interaction. [Abstract]

2024 Oct 17:15:1469180. PMID: 39484165
Front Pharmacol

Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT. [Abstract]

2021 May 10:12:670224. PMID: 34040532
Chem Biol Interact

Cyclophosphamide-induced iron homeostasis imbalance triggers ovarian toxicity through ferroptosis of ovarian granulosa cells in a mitophagy crosstalk manner. [Abstract]

2026 Jun 1:432:112047. PMID: 41861985
J Nutr Biochem

1,25(OH)2D3 ameliorates DSS-induced intestinal ferroptosis through the SIRT3-SOD2-mtROS pathway. [Abstract]

2025 Oct:144:109999. PMID: 40513839
Toxicology

Benzyl butyl phthalate promotes ferroptosis in Sertoli cells via disrupting ceruloplasmin-mediated iron balance. [Abstract]

2025 Mar:512:154078. PMID: 39921026
Chem Biol Interact

Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy. [Abstract]

2025 Feb 1:407:111368. PMID: 39746501
Toxicology

Ferroptosis contributes to lead-induced cochlear spiral ganglion neurons injury. [Abstract]

2024 Sep 12:509:153938. PMID: 39276841
Thromb Haemost

Macrophage ferroptosis promotes MMP2/9 overexpression induced by hemin in hemorrhagic plaque. [Abstract]

2024 Jun;124(6):568-580. PMID: 37696298
Chem Biol Interact

Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice. [Abstract]

2024 Feb 25:390:110870. PMID: 38220133
Chem Biol Interact

Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice. [Abstract]

2023 Oct 27:110788. PMID: 39491143
Chem Biol Interact

Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway. [Abstract]

2022 Aug 1:362:110004. PMID: 35661779
Bioorg Chem

DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancer. [Abstract]

2026 Aug 5:177:109901. PMID: 42048687
World J Diabetes

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction. [Abstract]

2021 Feb 15;12(2):124-137. PMID: 33594332
Biochim Biophys Acta Mol Basis Dis

Huaier counteracts sorafenib resistance in hepatocellular carcinoma by activating NCOA4-mediated ferritinophagy to induce ferroptosis via modulation of iron and lipid metabolism. [Abstract]

2026 Jun 3;1872(7):168313. PMID: 42242436
Mol Plant Pathol

Fungus Derived Indole-3-Acetic Acid Controls Developmental Conidial Death in Magnaporthe oryzae. [Abstract]

2026 Apr;27(4):e70252. PMID: 41905895
Mol Med Rep

Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis
. [Abstract]

2026 Mar;33(3):92. PMID: 41543167
Mol Med Rep

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway. [Abstract]

2026 Jan;33(1):24. PMID: 41201015
Mol Med Rep

Reduced iron bioavailability drives acute high‑altitude lung injury through HIF1α activation and mitophagy. [Abstract]

2025 Aug;32(2):215. PMID: 40444479
Biochim Biophys Acta Mol Basis Dis

Nuclear receptor coactivator 4 linked to follicular dysplasia in polycystic ovary syndrome: A key regulator that aggravates ovarian granulosa cells ferritinophagy and ferroptosis. [Abstract]

2025 Jun 17;1871(7):167955. PMID: 40553994
Biochim Biophys Acta Mol Basis Dis

PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease. [Abstract]

2025 Mar;1871(3):167645. PMID: 39743023
Sci Rep

APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer. [Abstract]

2026 Mar 15;16(1):13595. PMID: 41840064
Cancer Sci

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1. [Abstract]

2025 Aug;116(8):2256-2269. PMID: 40485050
Sci Rep

Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis. [Abstract]

2025 Aug 18;15(1):30197. PMID: 40825957
Sci Rep

RNA binding protein ALYREF regulates ferroptosis to facilitate LUAD growth and metastasis via promoting SLC7A11 mRNA stability. [Abstract]

2025 Jan 8;15(1):1351. PMID: 39779775
Sci Rep

Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis. [Abstract]

2025 Jan 7;15(1):1141. PMID: 39774712
Toxics

Effects on Iron Metabolism and System Xc- /GPX4 Pathway from Hydroquinone Suggest Ferroptosis of Jurkat Cells. [Abstract]

2024 Aug 31;12(9):644. PMID: 39330572
Sci Rep

Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin. [Abstract]

2024 Jun 21;14(1):14307. PMID: 38906931
Cancers (Basel)

Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism. [Abstract]

2025 Dec 27;18(1):92. PMID: 41514605
Cancers (Basel)

Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. [Abstract]

2022 Jan 11;14(2):345. PMID: 35053507
Oncol Rep

Schisandrin B exhibits anti‑proliferative effects by inducing ferroptosis in pancreatic cancer. [Abstract]

2026 Aug;56(2):147. PMID: 42318966
Neuropharmacology

Deferoxamine attenuates bone cancer pain via modulation of the RIG-I/CCL5 signaling pathway in rats. [Abstract]

2026 Aug 15:294:110974. PMID: 41999973
Oncol Rep

REV1‑targeting inhibitor JH‑RE‑06 induces ferroptosis via NCOA4‑mediated ferritinophagy in colorectal cancer cells. [Abstract]

2025 Dec;54(6):159. PMID: 40999956
Cell Signal

Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62. [Abstract]

2025 Nov:135:112024. PMID: 40721064
Mol Cell Biochem

STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO-1-mediated ferroptosis. [Abstract]

2025 Jul;480(7):4265-4281. PMID: 40087208
Cell Signal

HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism. [Abstract]

2025 Mar:127:111583. PMID: 39756501
J Cell Mol Med

Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway. [Abstract]

2024 Apr;28(8):e18335. PMID: 38652216
Oncol Rep

Inhibition of SND1 overcomes chemoresistance in bladder cancer cells by promoting ferroptosis. [Abstract]

2023 Jan;49(1):16. PMID: 36453257
Oncol Rep

Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression. [Abstract]

2021 Nov;46(5):240. PMID: 34558645
J Neurochem

Neuronal Damage Induced by Gradual Oxidative Stress in iPSC-Derived Neurons: Implications for Ferroptosis Involvement and ALS Drug Evaluation. [Abstract]

2025 Oct;169(10):e70246. PMID: 41017138
Poult Sci

Duck House Inhalable Particulate Matter Induces Lung Injury by Activating Ferroptosis. [Abstract]

2025 Apr 16;104(8):105169. PMID: 40403547
Neurochem Res

Ferritinophagy-Mediated Hippocampus Ferroptosis is Involved in Cognitive Impairment in Immature Rats Induced by Hypoxia Combined with Propofol. [Abstract]

2024 Jul;49(7):1703-1719. PMID: 38512425
Mol Nutr Food Res

Ethanol-Induced Hepatic Ferroptosis Is Mediated by PERK-Dependent MAMs Formation: Preventive Role of Quercetin. [Abstract]

2024 Apr;68(7):e2300343. PMID: 38501770
Mol Oncol

A protein complex of LCN2, LOXL2 and MMP9 facilitates tumour metastasis in oesophageal cancer. [Abstract]

2023 Nov;17(11):2451-2471. PMID: 37753805
Brain Res Bull

Ferroptosis related genes participate in the pathogenesis of spinal cord injury via HIF-1 signaling pathway. [Abstract]

2023 Jan:192:192-202. PMID: 36414158
iScience

Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response. [Abstract]

2021 Sep 25;24(10):103170. PMID: 34646996
Aquaculture

2024 Jan 30, 579, 740203.
Front Mol Biosci

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells. [Abstract]

2022 Jul 22:9:952608. PMID: 35936782
Biochim Biophys Acta Mol Cell Res

DHCR7 promotes granulosa cells ferroptosis and represents a potential therapeutic target in premature ovarian insufficiency. [Abstract]

2026 Jun 1;1873(6):120168. PMID: 42218966
FASEB J

Transcriptional Control by FOXO4 Regulates Trophoblast Differentiation and Safeguards Placental Development Through MITD1- and PCBP2-Mediated Redox Homeostasis. [Abstract]

2026 Jun 15;40(11):e71971. PMID: 42201761
FASEB J

RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux. [Abstract]

2025 Dec 31;39(24):e71369. PMID: 41408993
Water Biol Secur

2025 Nov 13.
FASEB J

Artesunate induces ferroptosis in osteosarcoma through NCOA4-mediated ferritinophagy. [Abstract]

2025 Apr 15;39(7):e70488. PMID: 40168090
FASEB J

Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway. [Abstract]

2023 Jun;37(6):e22992. PMID: 37219513
Fish Shellfish Immunol

Scale drop disease virus (SDDV) triggers ferroptosis both in mandarin fish (Siniperca chuatsi) and MFF-1 cells to facilitate virus infection via linking to transferrin receptor 1 (TfR1). [Abstract]

2025 Aug:163:110416. PMID: 40373888
Fish Shellfish Immunol

Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. [Abstract]

2023 Nov:142:109145. PMID: 37805110
FEBS J

Interferon-γ induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration. [Abstract]

2022 Apr;289(7):1968-1983. PMID: 34741776
Lab Invest

CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis. [Abstract]

2022 Dec;102(12):1323-1334. PMID: 35945269
J Photochem Photobiol B

Hypericin-mediated photodynamic therapy promotes apoptosis and inhibits fibrosis by inducing HMOX1-mediated ferroptosis in hypertrophic scar fibroblasts. [Abstract]

2025 Dec:273:113303. PMID: 41218547
J Cell Physiol

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. [Abstract]

2021 Apr;236(4):2725-2739. PMID: 32892384
J Cell Physiol

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin. [Abstract]

2020 Apr;235(4):3425-3437. PMID: 31556117
J Cell Physiol

Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. [Abstract]

2020 Apr;235(4):3329-3339. PMID: 31541463
J Cell Physiol

Pan-cancer analysis of iron metabolic landscape across the Cancer Genome Atlas. [Abstract]

2020 Feb;235(2):1013-1024. PMID: 31240715
J Cell Sci

Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells. [Abstract]

2022 Aug 1;135(15):jcs259090. PMID: 35775474
Neurotoxicology

FTH1-mediated iron dysregulation and ferroptosis in manganese-induced neurotoxicity. [Abstract]

2026 Jan:112:103367. PMID: 41412472
Mol Immunol

Transcription factor STAT1 upregulates IL-36γ to mediate the sensitivity of human nasal epithelial cells to ferroptosis and promote inflammatory progression in chronic rhinosinusitis. [Abstract]

2026 Aug:196:11-23. PMID: 42247985
J Med Virol

Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis. [Abstract]

2024 Oct;96(10):e29945. PMID: 39370874
Parasit Vectors

What exactly does the PfK13 C580Y mutation in Plasmodium falciparum influence?. [Abstract]

2023 Nov 16;16(1):421. PMID: 37974285
Nanotoxicology

Polystyrene nanoplastics promote tumor lung metastasis by inducing sodium overload in macrophages in an NMDAR-dependent way. [Abstract]

2026 May 19:1-18. PMID: 42154607
Toxicol Appl Pharmacol

PM2.5 enhances DRP1-mediated mitochondrial fission to induce ferroptosis and exacerbate asthma through the AHR-HSP90-PKM2 pathway. [Abstract]

2025 Oct 4:505:117590. PMID: 41052681
J Biochem Mol Toxicol

Excess iron accumulation mediated senescence in diabetic kidney injury. [Abstract]

2024 Apr;38(4):e23683. PMID: 38483099
ACS Chem Biol

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. [Abstract]

2022 Dec 16;17(12):3389-3406. PMID: 36446024
Nanotoxicology

Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis. [Abstract]

2022 Nov-Dec;16(9-10):829-843. PMID: 36660964
Arch Biochem Biophys

Role of protein disulfide isomerase in mediating sulfasalazine-induced ferroptosis in HT22 cells: The PDI-NOS-NO-ROS/lipid-ROS cascade. [Abstract]

2025 Jun:768:110366. PMID: 40023379
Exp Cell Res

Sensitivity of triple negative breast cancer cells to ATM-dependent ferroptosis induced by sodium selenite. [Abstract]

2024 Oct 1;442(2):114222. PMID: 39214329
Cell Biol Int

Golgi protein ACBD3 downregulation sensitizes cells to ferroptosis. [Abstract]

2024 Oct;48(10):1559-1572. PMID: 38953242
Cancer Med

Dihydroartemisinin Sensitizes Lung Cancer Cells to Cisplatin Treatment by Upregulating ZIP14 Expression and Inducing Ferroptosis. [Abstract]

2024 Oct;13(19):e70271. PMID: 39394878
Mol Carcinog

PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. [Abstract]

2023 Aug;62(8):1119-1135. PMID: 37144835
Arch Biochem Biophys

Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. [Abstract]

2023 Aug:744:109691. PMID: 37473980
Arch Biochem Biophys

Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway. [Abstract]

2023 Jul 1:742:109622. PMID: 37172672
J Diabetes Res

Metformin and Placental Ferroptosis in Gestational Diabetes: A Mechanistic Study. [Abstract]

2026;2026(1):e2226729. PMID: 42237524
Front Oncol

Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma. [Abstract]

2022 May 18:12:874900. PMID: 35664792
Reprod Toxicol

Iron overload compromises preimplantation mouse embryo development. [Abstract]

2021 Oct:105:156-165. PMID: 34481919
Front Oncol

Iron Regulates the Warburg Effect and Ferroptosis in Colorectal Cancer. [Abstract]

2021 May 18:11:614778. PMID: 34094899
Animal Model Exp Med

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis. [Abstract]

2025 Jan 23. PMID: 39846413
J Cancer Res Clin Oncol

Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4. [Abstract]

2024 Sep 23;150(9):429. PMID: 39311951
SLAS Discov

Reprint of: Detection and Impact of Hypoxic Regions in Multicellular Tumor Spheroid Cultures formed by Head and Neck Squamous Cell Carcinoma Cells Lines. [Abstract]

2023 Dec 13:100130. PMID: 38101574
Diabet Med

Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis. [Abstract]

2023 Jul;40(7):e15031. PMID: 36537855
SLAS Discov

Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines. [Abstract]

2022 Jan;27(1):39-54. PMID: 35058175
Food Chem Toxicol

CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway. [Abstract]

2025 Oct:204:115664. PMID: 40714179
Food Chem Toxicol

Ferroptosis promotes valproate-induced liver steatosis in vitro and in vivo. [Abstract]

2024 Oct:192:114926. PMID: 39147356
Food Chem Toxicol

Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo. [Abstract]

2022 Aug:166:113255. PMID: 35772596
J Immunol Res

Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis. [Abstract]

2022 Jun 17:2022:6833867. PMID: 35755168
Toxicol Lett

Erythrotoxicity of iron-doped cerium oxide nanoparticles is mediated by eryptosis. [Abstract]

2026 Jun:421:111922. PMID: 42155689
Tissue Cell

Glutaredoxin 1 promotes sorafenib resistance in renal cell carcinoma through ferroptosis suppression: Integrative bioinformatics analysis and experimental validation. [Abstract]

2026 Apr 9:102:103518. PMID: 41990693
J Steroid Biochem Mol Biol

E3 ubiquitin ligase PELI1 promotes ferroptosis in granulosa cells in PCOS by degrading Fth1. [Abstract]

2026 Jan 29:259:106948. PMID: 41620040
Tissue Cell

WTAP-mediated m6A modification of PRMT1 regulates cuproptosis to promote anaplastic thyroid carcinoma progression. [Abstract]

2026 Feb:98:103221. PMID: 41240789
3 Biotech

Rosmarinic acid induces ferroptosis in colon cancer: insights from AKR1C3/PTGS2 pathway and mitochondrial dysfunction. [Abstract]

2025 Nov;15(11):374. PMID: 41064160
J Inorg Biochem

Iridium(III) complexes as type I photosensitizers for hypoxic two-photon photodynamic therapy. [Abstract]

2025 Nov:272:113006. PMID: 40682924
Immunobiology

Deferoxamine attenuates sepsis-induced liver injury by suppressing ferroptosis. [Abstract]

2025 Oct 3;230(6):153125. PMID: 41066922
Exp Eye Res

PCBP1 modulates cellular iron homeostasis via targeting HIF-1α/HO-1 pathway and alleviates high-glucose-induced ferroptosis in HRMECs. [Abstract]

2025 Oct:259:110576. PMID: 40789503
J Appl Toxicol

Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways. [Abstract]

2025 Aug;45(8):1637-1648. PMID: 40288885
Kaohsiung J Med Sci

Dihydroartemisinin enhances gefitinib cytotoxicity against lung adenocarcinoma cells by inducing ROS-dependent apoptosis and ferroptosis. [Abstract]

2023 Jul;39(7):699-709. PMID: 37057810
J Neurosci Res

Iron overload facilitates neonatal hypoxic-ischemic brain damage via SLC7A11-mediated ferroptosis. [Abstract]

2023 Jul;101(7):1107-1124. PMID: 36929608
Discov Oncol

Ferroptotic resistance involved in PTEN-loss prostate cancer progression. [Abstract]

2025 Nov 25;16(1):2166. PMID: 41288888
PLoS One

Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells. [Abstract]

2025 May 22;20(5):e0322746. PMID: 40402956
Vet Microbiol

Autophagy is involved in Salmonella Typhimurium-induced ferroptosis in macrophages. [Abstract]

2025 Apr 27:305:110538. PMID: 40311251
J Invest Surg

Functional Study of the circRNA_0006393/miR-375/IGFBP4 Axis in Fracture Healing Associated with Male Idiopathic Osteoporosis. [Abstract]

2025 Dec;38(1):2535522. PMID: 40728000
J Mol Histol

The effect of USP17 knockdown on autophagic ferroptosis in gastric cancer by regulating the BNIP3-NCOA4-FTH1 axis. [Abstract]

2025 Jul 31;56(4):245. PMID: 40742478
J Nat Med

Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation. [Abstract]

2024 Jun;78(3):618-632. PMID: 38668832
Biochem Biophys Res Commun

Regorafenib promotes ferroptosis in acute myeloid leukemia by upregulating NOX4. [Abstract]

2025 Dec 15:792:152981. PMID: 41242297
Cancer Chemother Pharmacol

Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1. [Abstract]

2024 Dec 11;95(1):3. PMID: 39661165
Biochem Biophys Res Commun

Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. [Abstract]

2024 May 28:710:149895. PMID: 38593620
Biochem Biophys Res Commun

18β-glycyrrhetinic acid protects neuronal cells from ferroptosis through inhibiting labile iron accumulation and preventing coenzyme Q10 reduction. [Abstract]

2022 Dec 20:635:57-64. PMID: 36257193
Biochem Biophys Res Commun

Hypoxic preconditioning improves the survival and pro-angiogenic capacity of transplanted human umbilical cord mesenchymal stem cells via HIF-1α signaling in a rat model of bronchopulmonary dysplasia. [Abstract]

2022 May 21;605:111-118. PMID: 35316761
Biochem Biophys Res Commun

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma. [Abstract]

2019 Nov 12;519(3):533-539. PMID: 31537387
Onco Targets Ther

Aloperine Induces Ferroptosis of Colorectal Cancer Cells via the Nrf2 Pathway. [Abstract]

2026 Mar 21:19:575500. PMID: 41889434
Oncol Lett

Lung squamous cell carcinoma downregulates haptoglobin expression to inhibit M2 macrophage ferroptosis via the hemoglobin-dependent CD163/HO-1 pathway. [Abstract]

2026 Mar 30;31(5):203. PMID: 41987865
Neuroreport

Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation. [Abstract]

2022 Nov 2;33(16):705-713. PMID: 36165031
Cardiovasc Pathol

Iron deficiency drives pathological cardiac remodeling and diastolic dysfunction associated with inhibition of AMPK-mTORC1 signaling. [Abstract]

2026 Jul-Aug:83:107828. PMID: 42019832
Curr Eye Res

HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe2+ Production. [Abstract]

2023 Jan;48(1):25-33. PMID: 36300537
bioRxiv

2026 Jun 2.
bioRxiv

2026 Jun 16.
SSRN

2026 May 15.
Res Sq

2026 Jan 9.
SSRN

2026 Jan 2.
bioRxiv

Arterial iron regulates vasodilation during anemia via endothelial holo-alpha globin. [Abstract]

2025 Dec 12:2025.12.09.693297. PMID: 41415386
SSRN

2025 Sep 16.
Res Sq

2025 Aug 08.
SSRN

2025 Aug 21.
Wayne State University

2025.
SSRN

2025 Jun 6.
SSRN

2025 Feb 21.
SSRN

2025 Mar 20.
bioRxiv

2025 March 18.
SSRN

2024 Nov 18.
Res Sq

2024 Oct 27.
Sci Total Environ

DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC-1α pathway. [Abstract]

2024 Dec 1:954:176497. PMID: 39326761
Biomed Pharmacother

Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation. [Abstract]

2024 Oct:179:117309. PMID: 39151312
Chemosphere

Indeno[1,2,3-cd]pyrene enhances the sensitivity of airway epithelial cells to ferroptosis and aggravates asthma. [Abstract]

2024 Sep:363:142885. PMID: 39025314
Heliyon

Celastrol induces ferroptosis by suppressing RRM2 in hepatocellular carcinoma. [Abstract]

2024 Jul 2;10(13):e33936. PMID: 39071636
SSRN

2024 Jun 18.
Biomed Pharmacother

Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes. [Abstract]

2024 Jun:175:116727. PMID: 38733771
SSRN

2024 Apr 23.
Biomed Pharmacother

Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η. [Abstract]

2024 May:174:116542. PMID: 38574620
Aging (Albany NY)

Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis. [Abstract]

2024 Apr 19;16(8):7277-7292. PMID: 38643467
Sci Total Environ

Ferroptosis participated in inhaled polystyrene nanoplastics-induced liver injury and fibrosis. [Abstract]

2024 Mar 15:916:170342. PMID: 38278228
Heliyon

YAP promotes the healing of ischemic wounds by reducing ferroptosis in skin fibroblasts through inhibition of ferritinophagy. [Abstract]

2024 Jan 16;10(2):e24602. PMID: 38298641
Research Square Preprint

2023 Nov 17.
Research Square Preprint

2023 Oct 18.
Research Square Preprint

2023 Oct 13.
SSRN

2023 Sep 18.
Research Square Preprint

2023 Sep 18.
Phytomed Plus

2023 Aug 25, 100482.
Research Square Preprint

2023 Jul 26.
Research Square Preprint

2023 Apr 25.
bioRxiv

2023 Feb 8.
Research Square Print

2023 Feb 20.
Oxid Med Cell Longev

Carbonic Anhydrase IX Controls Vulnerability to Ferroptosis in Gefitinib-Resistant Lung Cancer. [Abstract]

2023 Jan 31:2023:1367938. PMID: 36760347
Research Square Print

2022 Jul.
Oxid Med Cell Longev

Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying circ_0050205 Attenuate Intervertebral Disc Degeneration. [Abstract]

2022 Jul 5:2022:8983667. PMID: 35847582
Research Square Preprint

2022 Feb.
Oxid Med Cell Longev

Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis. [Abstract]

2022 Jan 15:2022:9947191. PMID: 35075382
Research Square Preprint

2022 Jan.
Research Square Preprint

2021 Oct.
Research Square Preprint

2021 Oct.
Environ Toxicol

Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes. [Abstract]

2021 Apr;36(4):520-529. PMID: 33166055
Nanoscale Res Lett

Fe(II) and Tannic Acid-Cloaked MOF as Carrier of Artemisinin for Supply of Ferrous Ions to Enhance Treatment of Triple-Negative Breast Cancer. [Abstract]

2021 Feb 23;16(1):37. PMID: 33620584
Oxid Med Cell Longev

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo. [Abstract]

2021 Feb 10:2021:6670497. PMID: 33628376
Research Square Preprint

2021 Jan.
bioRxiv

2020 Dec 14.
Research Square Preprint

2020 Oct.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 10 mg/mL (17.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7835 mL

8.9177 mL

17.8355 mL

5 mM

0.3567 mL

1.7835 mL

3.5671 mL

10 mM

0.1784 mL

0.8918 mL

1.7835 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (2.23 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.25 mg/mL (2.23 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (2.23 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
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LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
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Other Report (2659 KB)
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Verweise

[1]. Duscher D, et al. Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing. Plast Reconstr Surg. 2017 Mar;139(3):695e-706e. [Content Brief]

[2]. Dongiovanni P, et al. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol. 2008 Mar;172(3):738-47. [Content Brief]

[3]. Wang G, et al. In vitro assessment of deferoxamine on mesenchymal stromal cells from tumor and bone marrow. Environ Toxicol Pharmacol. 2017 Jan;49:58-64. [Content Brief]

[4]. Wu Y, et al. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. Neurochem Int. 2010 Oct;57(3):198-205. [Content Brief]

[5]. Bellotti D, et al. Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator. Molecules. 2021 May 28;26(11):3255. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7835 mL	8.9177 mL	17.8355 mL	44.5887 mL
	5 mM	0.3567 mL	1.7835 mL	3.5671 mL	8.9177 mL
	10 mM	0.1784 mL	0.8918 mL	1.7835 mL	4.4589 mL
	15 mM	0.1189 mL	0.5945 mL	1.1890 mL	2.9726 mL

Deferoxamine

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Deferoxamine

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