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Art. -Nr.: HY-N10421

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Dihydrocubebin

(Synonyms: (-)-Dihydrocubebin)

Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4).

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CAS. Nr.: 24563-03-9
Formel: C₂₀H₂₂O₆
Molecular Weight:358.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Dihydrocubebin Chemical Structure

CAS. Nr.: 24563-03-9

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Dihydrocubebin is a compound isolated from Piper cubeba as potent and selective inhibitors against cytochrome P450 3A4 (CYP3A4)^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
BC	IC₅₀	>5 μg/mL Compound: dihydrocubebin	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 16038539]
KB	IC₅₀	>5 μg/mL Compound: dihydrocubebin	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 16038539]
MCF7	IC₅₀	89.4 μM Compound: 9	Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs Cytotoxicity against human MCF7 cells assessed as [3H]-hypoxanthine incorporation after 48 hrs	[PMID: 20954722]
NCI-H187	IC₅₀	>5 μg/mL Compound: dihydrocubebin	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 16038539]
Vero	IC₅₀	83.8 μM Compound: 9	Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs Cytotoxicity against african green monkey Vero cells assessed as [3H]-hypoxanthine incorporation after 48 hrs	[PMID: 20954722]

Chemical Information

CAS. Nr. 24563-03-9
Molecular Weight 358.39
Formel C₂₀H₂₂O₆
SMILES

OC[C@H](CC1=CC=C(OCO2)C2=C1)[C@H](CO)CC3=CC=C(OCO4)C4=C3
Synonyms

(-)-Dihydrocubebin
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Usia T, et al. Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: mechanism-based inhibition. Life Sci. 2005;76(20):2381-2391. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Dihydrocubebin

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