Mmp13 - matrix metallopeptidase 13 Gene
Species: Rattus norvegicus
About Mmp13
This gene has 1 transcript (splice variant), 203 orthologues, 23 paralogues and is associated with 44 phenotypes. Biased expression in Thymus (RPKM 2.9), Muscle (RPKM 1.6) and 5 other tissues.
Summary
Enables several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including animal organ development; embryonic hindlimb morphogenesis; and estrous cycle. Located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including degenerative disc disease; gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13). [provided by Alliance of Genome Resources, Apr 2022]
Mmp13 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_133530.1 | NP_598214.1 | collagenase 3 precursor |
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Mmp13 Protein Structure
PG_binding_1: pfam01471 (39 - 91)
Peptidase_M10: pfam00413 (112 - 267)
HX: cd00094 (281 - 471)
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- 472 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
collagenase 3 |
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