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Art. -Nr.: HY-182031

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JS04

JS04 is a EGFR^L858R/T790M kinase inhibitor. JS04 activates both endogenous and exogenous apoptosis (apoptosis) pathways and induces G2/M phase arrest of the cell cycle. JS04 is applicable to the research of drug-resistant non-small cell lung cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₀H₂₃ClN₆
Molecular Weight:382.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

JS04 Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

EGFR^L858R/T790M

Bcl-2

Bcl-xL

Alle EGFR Isoform-spezifische Produkte anzeigen :

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

JS04 (72 h) potently inhibits the proliferation of H1975 and A549 non-small cell lung cancer (NSCLC) cells, with IC₅₀ values of 8.11 μM and 11.58 μM, respectively; meanwhile, this compound exhibits a favorable safety window against human Hs27 fibroblasts, with a selectivity index of 2.52^[1].
JS04 (10-20 μM; 48 h) induces dose-dependent apoptosis in H1975 cells^[1].
JS04 (10-20 μM; 48 h) induces G₂/M cell cycle arrest in H1975 cells^[1].
JS04 (72 h) can simultaneously activate the intrinsic apoptotic pathway (downregulating the expression of BCL-2, BCL-xL and Survivin) and the extrinsic apoptotic pathway (upregulating the expression of TRAIL R2/DR5)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

H1975 NSCLC
Concentration:

10 and 20 μM
Incubation Time:

48 h
Result:

At 20 μM, induced 74% total apoptotic cell death.
At 10 μM, produced a lower level of apoptosis compared to 20 μM, as confirmed by reduced viable cell populations.

Cell Cycle Analysis^[1]

Cell Line:

H1975 NSCLC
Concentration:

10 and 20 μM
Incubation Time:

48 h
Result:

At 20 μM, caused an approximately 3 to 4-fold increase in the G₂/M cell population (35% of cells in G₂/M phase), with a concomitant decrease in G₀/G₁ phase cells.

In Vivo

JS04 (6.25-100 μM; immersion treatment; continuous administration; from 5.5 to 6 hours post-fertilization to 96 hours post-fertilization) exhibits favorable acute safety in zebrafish (Danio rerio) embryos^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

AB-WT (fertilised embryos)^[1]
Dosage:

6.25 μM; 12.5 μM; 25 μM; 50 μM; 100 μM
Administration:

immersion; continuous; 5.5-6 hpf through 96 hpf
Result:

Caused 100% embryo mortality at 100 μM and 96 hpf.
Resulted in < 20% mortality across all time points at 6.25, 12.5, and 25 μM.

Chemical Information

Molecular Weight 382.89
Formel C₂₀H₂₃ClN₆
SMILES

CNC1=NC(NC2=CC=C(C=C2)N3CCN(CC3)C)=NC4=CC(Cl)=CC=C41
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sivam J, et al. Novel 2-Anilinoquinazoline derivatives as apoptosis-inducing agents in drug-resistant NSCLC cells: Integrating biological and computational evaluation. Bioorg Chem. Published online February 26, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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JS04

Alle EGFR Isoform-spezifische Produkte anzeigen

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

JS04 Related Classifications

HY-182031 Related Classifications