Art. -Nr.: HY-N4247

Kuwanon G

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Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis.

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Reinheit: 99.45%
CAS. Nr.: 75629-19-5
Formel: C₄₀H₃₆O₁₁
Molecular Weight:692.71

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Kuwanon G Chemical Structure

CAS. Nr.: 75629-19-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle GSK-3 Isoform-spezifische Produkte anzeigen :

Alle MMP Isoform-spezifische Produkte anzeigen :

Alle mTOR Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	13.2 x 10^-5 M Compound: kumanon G	Inhibition of thromboxane B2 formation in Wistar King platelets Inhibition of thromboxane B2 formation in Wistar King platelets	[PMID: 3097265]
Platelet	IC₅₀	8.93 x 10^-5 M Compound: kumanon G	Inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid formation in Wistar King platelets Inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid formation in Wistar King platelets	[PMID: 3097265]

In Vitro

Kuwanon G (5-70 μM; 48 h) can inhibit the apoptosis of HT22 cells induced by Advanced glycation end products (HY-NP165) and the elevation of MDA and ROS levels, and restore the intracellular Ach level. The mechanism involves the PI3K/Akt/GSK3αβ signaling pathway^[1].
Kuwanon G (0-20 μg/mL; 0-10 min) has an MIC of 8.0 μg/mL for Streptococcus mutans^[2].
Kuwanon G (0-160 μM; 1-24 h) can inhibit the proliferation, migration and invasion, promote cell apoptosis, and inhibit the expression of MMP2 and MMP9 in gastric cancer cells. The mechanism involves the inhibition of the PI3K/AKT/mTOR pathway^[3].
Kuwanon G (2-20 μM; 24 h) can inhibit lipid accumulation and the mRNA levels of inflammatory factors in RAW 264.7 cells treated with ox-LDL (HY-NP135). The mechanism involves the activation of the LXRα-ABCA1/ABCG1 pathway and the inhibition of NF-κB^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

MGC 803, HGC 27, AGS and SGC-7901 cells
Concentration:

0, 1.25, 5, 10, 20, 40, 80 and 160 μM
Incubation Time:

24 h
Result:

Inhibited the proliferation of gastric cancer cells in a concentration-dependent manner.

Western Blot Analysis^[4]

Cell Line:

RAW264.7 cells treated ox-LDL (HY-NP135)
Concentration:

20 μM
Incubation Time:

24 h
Result:

Increased the levels of ABCA1, ABCG1 and LXRα.

In Vivo

Kuwanon G (20-40 μM; 2 weeks) exhibits anti-tumor activity in the MGC 803 xenograft mouse model^[3].
Kuwanon G (5 mg/kg; intraperitoneal injection; once every other day; 16 weeks) has an ameliorative effect in the atherosclerotic mouse model of ApoE^-/- fed a high-fat diet^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ApoE-deficient (ApoE^-/-) mice treated high-fat diet^[4]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection; once every other day; 16 weeks
Result:

Remarkably reduced the atherosclerotic lesion areas and macrophage content.
Reduced hyperlipidemia and serum inflammatory cytokines in vivo.

Chemical Information

CAS. Nr. 75629-19-5
Appearance Solid
Molecular Weight 692.71
Formel C₄₀H₃₆O₁₁
Color Light yellow to yellow
SMILES

O=C1C(C/C=C(C)\C)=C(C2=CC=C(O)C=C2O)OC3=C([C@H]4C=C(C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (72.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4436 mL

7.2180 mL

14.4361 mL

5 mM

0.2887 mL

1.4436 mL

2.8872 mL

10 mM

0.1444 mL

0.7218 mL

1.4436 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gan WJ, et al. Kuwanon G protects HT22 cells from advanced glycation end product-induced damage. Exp Ther Med. 2021 May;21(5):425. [Content Brief]

[2]. Park KM, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol. 2003 Feb;84(2-3):181-5. [Content Brief]

[3]. Geng Z, et al. [Kuwanon G inhibits growth, migration and invasion of gastric cancer cells by regulating the PI3K/AKT/mTOR pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Aug 20;44(8):1476-1484. [Content Brief]

[4]. Liu XX, et al. Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages. Toxicol Appl Pharmacol. 2018 Feb 15;341:56-63. [Content Brief]

[5]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4436 mL	7.2180 mL	14.4361 mL	36.0901 mL
	5 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2180 mL
	10 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	15 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	20 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	25 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL
	30 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	40 mM	0.0361 mL	0.1805 mL	0.3609 mL	0.9023 mL
	50 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL
	60 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6015 mL

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Kuwanon G

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