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Art. -Nr.: HY-187685

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L 696418

L 696418 is a MMP-3 inhibitor with a K_i value of 310 nM. L 696418 inhibits MMP-3 activity, thereby preventing the release of proteoglycans from cartilage. L 696418 reduces proteoglycan release in rabbit knee joints exposed to interleukin-1β (IL-1β). L 696418 can be used in research related to cartilage degradation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 147485-09-4
Formel: C₂₅H₃₃N₃O₄
Molecular Weight:439.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

L 696418 Chemical Structure

CAS. Nr.: 147485-09-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

MMP-3

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In Vivo

Intravenous administration of L 696418 inhibits proteoglycan release by approximately 50% in rabbit knee joints treated with intra-articular injection of human MMP-3 and IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 147485-09-4
Molecular Weight 439.55
Formel C₂₅H₃₃N₃O₄
SMILES

C[C@H](C(O)=O)N[C@H](C(N[C@@H](CC(C)C)C(NC1=CC=CC=C1)=O)=O)CCC2=CC=CC=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Esser CK, et al. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. Journal of medicinal chemistry. 1997 Mar 14;40(6):1026-40.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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L 696418

Alle MMP Isoform-spezifische Produkte anzeigen